AI Article Synopsis
- Hypereosinophilia is a rare condition that can occur in individuals of any age, especially when it's severe and long-lasting.
- A case study of a Saudi female newborn shows severe hypereosinophilia with high eosinophil levels during a respiratory illness, linked to a strong cytomegalovirus (CMV) infection and a specific gene mutation (STAT1).
- Treatment with oxygen, antivirals, and steroids led to significant improvement within 24 hours, highlighting the importance of considering genetic factors in unusual immune responses to infections.
Article Abstract
Hypereosinophilia is a rare presentation in all age groups, particularly when it is severe, persistent, and progressive. We describe the clinical characteristics and course of severe hypereosinophilia in a full-term Saudi female neonate. A febrile respiratory illness evolved with a progressive increase in peripheral blood leukocyte and eosinophil counts, reaching 44.9% of leukocytes and an absolute value of 57,000 cells/µl. Different etiological examinations (for viral, bacterial, immunodeficiency, hyper IgE syndrome, gene mutations) revealed extremely high CMV antigenemia and a homozygous mutation in the STAT1 gene. Anhelation was relieved by oxygen and anti-viral treatment. Steroids brought a dramatic response in peripheral blood counts within 24 h. After a 6-week course of antiviral and steroid treatment at home, she had an excellent general condition. Conclusion: Although a rare pathology, it is important to consider genetic disorders when there is an atypical immune response to viral infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200823 | PMC |
| http://dx.doi.org/10.1186/s12887-024-04846-4 | DOI Listing |
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