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A central role of stimulator of interferon genes' adaptor protein in defensive immune response.
Immunol Res
January 2025
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Cytotoxic DNAs, methylation, histones and histones binding proteins are speculated to induce DNA sensors. Under stressed condition, the antigenic patterns, PAMPs and DAMPs, trigger the hyperactive innate response through DNA, DNA-RNA hybrids, oligonucleotides, histones and mtDNA to initiate cGAMP-STING-IFN I cascade. HSV -1&2, HIV, Varicella- Zoster virus, Polyomavirus, Cytomegalovirus, and KSHV negatively regulate the STING-MAVS-TBK-1/1KKE pathway.
View Article and Find Full Text PDFCorrectional officers and the ongoing health implications of prison work.
Health Justice
December 2024
Memorial University of Newfoundland, St. John's, Canada.
Correctional Service Providers (CSP), including Correctional officers (COs), are key front-line figures in prisons globally, with responsibility for a wide range of daily prison operations. Over the past decade, research on prison staff has massively grown. However, the portrait this scholarship draws is concerning.
View Article and Find Full Text PDFFingerprint resemblance amongst siblings and non-siblings - Forensic and anthropological implications.
Naturwissenschaften
January 2025
Department of Anthropology (UGC Centre of Advanced Study), Panjab University, Sector-14, Chandigarh, India.
Fingerprints hold a crucial position in forensic science, primarily for identification purposes, with thumbprints emerging as the most frequently recovered evidence at crime scenes. The main purpose of the present study was to conduct a comparative analysis of thumbprints of siblings and non-sibling pairs to investigate resemblance and similarities in fingerprint patterns. Thumbprints of 144 individuals (72 siblings and 72 non-siblings) from 36 families were obtained.
View Article and Find Full Text PDFCDK5: Insights into its roles in diseases.
Mol Biol Rep
January 2025
Institute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China.
Cyclin-dependent kinase 5 (CDK5), a unique member of the CDK family, is a proline-directed serine/threonine protein kinase with critical roles in various physiological and pathological processes. Widely expressed in the central nervous system, CDK5 is strongly implicated in neurological diseases. Beyond its neurological roles, CDK5 is involved in metabolic disorders, psychiatric conditions, and tumor progression, contributing to processes such as proliferation, migration, immune evasion, genomic stability, and angiogenesis.
View Article and Find Full Text PDFZebrafish modeling of atypical PML-RARA isoform from acute promyelocytic leukemia patient and its implications for clinical treatment.
Ann Hematol
January 2025
Department of Hematology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China.
Acute promyelocytic leukemia (APL) is driven by the specific fusion gene PML-RARA produced by chromosomal translocation. Three classic isoforms, L, V, and S, are found in more than 95% of APL patients. However, atypical PML-RARA isoforms are usually associated with uncertain disease progression and treatment prognosis.
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