AI Article Synopsis
- Epithelial-mesenchymal transition (EMT) is a key process in cancer metastasis influenced by TGF-β signaling.
- Non-coding RNAs like microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) play crucial roles in regulating EMT and TGF-β pathways, affecting gene expression.
- The review highlights the established role of miRNAs and the emerging significance of lncRNAs and circRNAs in cancer progression.
Article Abstract
Epithelial-mesenchymal transition (EMT) is a major contributor to metastatic progression and is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are tightly controlled by non-coding RNAs - including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) - that collectively have major impacts on gene expression and resulting cellular states. While miRNAs are the best characterised regulators of EMT and TGF-β signaling and the miR-200-ZEB1/2 feedback loop plays a central role, important functions for lncRNAs and circRNAs are also now emerging. This review will summarise our current understanding of the roles of non-coding RNAs in EMT and TGF-β signaling with a focus on their functions in cancer progression.
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| http://dx.doi.org/10.1016/j.semcancer.2024.06.001 | DOI Listing |
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