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and formula alleviates depressive behaviors microglia regulation in an unpredictable chronic mild stress animal model.
J Tradit Complement Med
January 2025
Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan.
Background And Aim: (CM) and (AM) are medicinal mushrooms with potential applications in the treatment of mood disorders, including depression and anxiety. While research suggests that both CM and AM possess anti-inflammatory properties and hold potential for treating depression when administered separately, there is limited knowledge about their efficacy when combined in a formula, as well as the underlying mechanism involving the modulation of microglia.
Experimental Procedure: Rats received oral administrations of the low-dose formulation, medium-dose formulation, and high-dose formulation over 28 consecutive days as part of the UCMS protocols.
Phylogenomic insights into the taxonomy, ecology, and mating systems of the lorchel family Discinaceae (Pezizales, Ascomycota).
Mol Phylogenet Evol
January 2025
Department of Ecology and Evolutionary Biology and University of Michigan Herbarium, University of Michigan, Ann Arbor, MI 48109, USA.
Lorchels, also known as false morels (Gyromitra sensu lato), are iconic due to their brain-shaped mushrooms and production of gyromitrin, a deadly mycotoxin. Molecular phylogenetic studies have hitherto failed to resolve deep-branching relationships in the lorchel family, Discinaceae, hampering our ability to settle longstanding taxonomic debates and to reconstruct the evolution of toxin production. We generated 75 draft genomes from cultures and ascomata (some collected as early as 1960), conducted phylogenomic analyses using 1542 single-copy orthologs to infer the early evolutionary history of lorchels, and identified genomic signatures of trophic mode and mating-type loci to better understand lorchel ecology and reproductive biology.
View Article and Find Full Text PDFBlobby is a synaptic active zone assembly protein required for memory in Drosophila.
Nat Commun
January 2025
Freie Universität Berlin, Institute for Biology and Genetics, Berlin, Germany.
At presynaptic active zones (AZs), scaffold proteins are critical for coordinating synaptic vesicle release and forming essential nanoarchitectures. However, regulatory principles steering AZ scaffold assembly, function, and plasticity remain insufficiently understood. We here identify an additional Drosophila AZ protein, "Blobby", essential for proper AZ nano-organization.
View Article and Find Full Text PDFALSUntangled #77: Psilocybin.
Amyotroph Lateral Scler Frontotemporal Degener
December 2024
Department of Neurology, Duke University, Durham, NC, USA.
Article Synopsis
- ALSUntangled examines alternative treatments for ALS, focusing on psilocybin, a psychedelic compound from mushrooms.
- Psilocybin may theoretically help slow ALS due to its ability to cross the blood-brain barrier and influence neurogenesis and inflammation, but there's no existing research specifically on its effects in ALS patients.
- Due to potential risks of psychological side effects and lack of supporting evidence, the use of psilocybin for ALS progression is not currently endorsed.
Maistero-2, a Novel Probe for Sterols: Application for Visualizing Cellular Cholesterol.
Methods Mol Biol
December 2024
Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.
Maistero-2 is a novel, non-toxic cholesterol-binding protein derived from an edible mushroom Grifola frondosa mRNA. Maistero-2 specifically binds to lipid membranes containing 3-hydroxy sterols with a lower cholesterol concentration threshold than cholesterol-binding domain 4 (D4) of perfringolysin O (PFO) and anthrolysin O (ALO). Maistero-2 binding is particularly sensitive to the size and conformation of the A-, B-, and D-ring of sterols but not very sensitive to modifications of the isooctyl side chain commonly found in phytosterols.
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