AI Article Synopsis
- A new method for creating nitrones has been developed using a palladium-based technique that combines nitro compounds and alcohols.
- This process is mild, easy to use, doesn't require additional chemicals, and can be scaled up for larger production.
- Nitrones are important building blocks for various chemical compounds and can be efficiently produced from inexpensive, readily available materials using this method.
Article Abstract
A novel methodology for the synthesis of nitrones via palladium-catalyzed redox cross-coupling of nitro compounds and alcohols is established. The protocol is a mild, convenient, ligand-free, and scalable synthesis method that can be compatible with various nitro compounds and alcohols. Nitrone is a significant multifunctional platform synthon which can be synthesized directly and efficiently via this tactic from commercially available and cheap raw materials.
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| http://dx.doi.org/10.1021/acs.joc.4c00512 | DOI Listing |
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