AI Article Synopsis

  • - Several types of airway stents exist for treating central airway obstructions, but an ideal stent that addresses various challenges has yet to be developed.
  • - Researchers created a bioresorbable tracheal stent prototype using 3D printing, testing it in rabbits to assess clinical tolerance and biocompatibility, ultimately focusing on improving functionality based on previous issues with similar stents.
  • - The most successful prototype, GSP2, demonstrated good tolerance, minimal migration, and acceptable biocompatibility due to its unique helix-shaped surface, paving the way for further studies in larger animal models.

Article Abstract

To date, several types of airway stents are available to treat central airway obstructions. However, the ideal stent that can overcome anatomical, mechanical and microbiological issues is still awaited. In addition, therapeutic effect and self-elimination of these stents are desirable properties, which pose an additional challenge for development and manufacturing. We aimed to create a prototype bioresorbable tracheal stent with acceptable clinical tolerance, fit and biocompatibility, that could be tested in a rabbit model and in the future be further optimized to enable drug-elution and ensure local therapeutic effect. Twenty-one New Zealand White Rabbits received five different types of bioresorbable tracheal stents, 3D-printed from poly(D,L-lactide-co-ε-caprolactone) metacrylates. Various configurations were tested for their functionality and improved until the best performing prototype could undergo detailed in vivo assessment, regarding clinical tolerance, migration and biocompatibility. Previously tested types of 3D printed stents in our preliminary study required improvement due to several problems, mainly related to breakage, unreliable stability and/or migration within the trachea. Abandoned or refined pre-prototypes were not analyzed in a comparative way. The final best performing prototype stent (GSP2 (Group Stent Prototype 2), n = 8) allowed a transoral application mode and showed good clinical tolerance, minimal migration and acceptable biocompatibility. The good performance of stent type GSP2 was attributed to the helix-shaped surface structure, which was therefore regarded as a key-feature. This prototype stent offers the possibility for further research in a large animal model to confirm the promising data and assess other properties such as bioresorption.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198857PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0300847PLOS

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