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Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis.
Open Med (Wars)
December 2024
Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Background: Atherosclerosis is a lipid-driven inflammatory disease characterized by plaque formation in major arteries. These plaques contain lipid-rich macrophages that accumulate through monocyte recruitment, local macrophage differentiation, and proliferation.
Objective: We identify the macrophage subsets that are closely related to atherosclerosis and reveal the key pathways in the progression of atherosclerotic disease.
SMALL BUT MIGHTY: CHARACTERIZATION OF VB_SPY_7, A LYTIC PHAGE TARGETING STREPTOCOCCUS PYOGENES.
Georgian Med News
October 2024
1G. Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia.
The emergence of antibiotic-resistant pathogens necessitates alternative therapies for treating microbial infections, especially in the oral cavity and upper respiratory tract. Our team has developed Phage Pastilles, a controlled-release formulation containing bacteriophages that target common pathogens, including Streptococcus pyogenes, Streptococcus salivarius, Staphylococcus aureus, Enterococcus faecalis, and E. coli.
View Article and Find Full Text PDFSENP2 negatively regulates RIG-I/MDA5 mediated innate immunity in black carp.
Fish Shellfish Immunol
December 2024
State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, China; Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, 410081, China. Electronic address:
Mammalian SUMO specific peptidase 2 (SENP2) plays vital roles in a variety of biological procedures including the immune response. However, the effects of teleost SENP2 are still mostly unexplored. In this study, the SENP2 of black carp (Mylopharyngodon piceus) was cloned and characterized.
View Article and Find Full Text PDFProgress of Chinese Medicine in Regulating Microglial Polarization against Alzheimer's Disease.
Am J Chin Med
December 2024
Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P. R. China.
Alzheimer's disease (AD), the predominant form of dementia, is a neurodegenerative disorder of the central nervous system (CNS) characterized by a subtle onset and a spectrum of cognitive and functional declines. The clinical manifestation of AD encompasses memory deficits, cognitive deterioration, and behavioral disturbances, culminating in a severe impairment of daily living skills. Despite its high prevalence, accounting for 60-70% of all dementia cases, there remains an absence of curative therapeutics.
View Article and Find Full Text PDF3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer's disease via machine learning.
Acta Neuropathol Commun
December 2024
Department of Ophthalmology and Visual Sciences, The University of British Columbia, 2550 Willow St. Room 375, Vancouver, BC, V5Z 3N9, Canada.
Alzheimer's Disease (AD) is a debilitating neurodegenerative disease that affects 47.5 million people worldwide. AD is characterised by the formation of plaques containing extracellular amyloid-β (Aβ) and neurofibrillary tangles composed of hyper-phosphorylated tau proteins (pTau).
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