Pedunculated Neoplasm of the Vulva.

Am J Dermatopathol

Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

Published: October 2024

AI Article Synopsis

  • - Extramammary Paget disease (EMPD) is a rare skin cancer often seen as eczema-like lesions in areas with many sweat glands, like the perineum.
  • - A 65-year-old woman had EMPD appear as a prominent neoplasm; after misdiagnosis and treatment, a biopsy confirmed EMPD.
  • - Following surgery, the patient experienced brain metastases, highlighting the need to understand EMPD better for effective treatment and the significance of recognizing unusual cases for early intervention.

Article Abstract

Extramammary Paget disease (EMPD) is a rare cutaneous malignancy, typically presenting as eczema-like lesions in areas rich in apocrine glands such as the perineum. Here, we report a case of EMPD presenting as a prominent pedunculated neoplasm in a 65-year-old woman. Despite initial misdiagnosis and treatment, biopsy confirmed EMPD infiltration. Following surgical excision, the patient developed brain metastases, indicating a poor prognosis. EMPD's pathogenesis remains unclear, but distinguishing primary from secondary forms is crucial for prognosis and treatment. Our case underscores the importance of recognizing atypical EMPD presentations for timely intervention and improved outcomes.

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http://dx.doi.org/10.1097/DAD.0000000000002764DOI Listing

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