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A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types. | LitMetric

AI Article Synopsis

  • The mammalian cortex consists of different cell types that have specific properties, which are important for understanding how the cortex functions in both health and disease.
  • Researchers utilized data from mouse and human studies to identify marker genes and enhancers for various cortical cell types, creating a comprehensive set of tools for targeting these cells specifically.
  • They introduced fifteen new transgenic driver lines, two new reporter lines, and over 800 enhancer AAVs, facilitating a wide range of experimental approaches to study the mammalian cortex and its functions.

Article Abstract

The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is essential for understanding its function in health and disease. We used transcriptomic and epigenomic cortical cell type taxonomies from mouse and human to define marker genes and putative enhancers and created a large toolkit of transgenic lines and enhancer AAVs for selective targeting of cortical cell populations. We report evaluation of fifteen new transgenic driver lines, two new reporter lines, and >800 different enhancer AAVs covering most subclasses of cortical cells. The tools reported here as well as the scaled process of tool creation and modification enable diverse experimental strategies towards understanding mammalian cortex and brain function.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11195086PMC
http://dx.doi.org/10.1101/2024.06.10.597244DOI Listing

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