Self-assembly of enzymes and prodrugs with clickable amino acids for nucleus-targeted cancer therapy.

Chem Commun (Camb)

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.

Published: July 2024

A nucleus-targeted nanocomposite was prepared by clickable amino acid-tuned one-step co-assembly of proteins and chemotherapeutics. The nanocomposite with favorable pharmacokinetic behavior can effectively accumulate in the nucleus, thereby significantly enhancing the anticancer therapeutic effect both and .

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Source
http://dx.doi.org/10.1039/d4cc02377cDOI Listing

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