AI Article Synopsis
- Nonpharmaceutical interventions (NPIs) during the COVID-19 pandemic have changed how respiratory syncytial virus (RSV) subtypes, specifically RSV-A and RSV-B, behave globally.
- The study used a model based on historical data from the UK and Finland to show that RSV-A is likely to dominate over RSV-B shortly after NPIs were implemented.
- The findings, supported by a global genetic dataset, suggest RSV-A's increased prevalence post-pandemic may influence the effectiveness of new vaccines and treatments for RSV in infants and high-risk groups.
Article Abstract
Nonpharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic have disrupted the dynamics of respiratory syncytial virus (RSV) on a global scale; however, the cycling of RSV subtypes in the pre- and post-pandemic period remains poorly understood. Here, we used a two subtype RSV model supplemented with epidemiological data to study the impact of NPIs on the two circulating subtypes, RSV-A and RSV-B. The model is calibrated to historic RSV subtype data from the United Kingdom and Finland and predicts a tendency for RSV-A dominance over RSV-B immediately following the implementation of NPIs. Using a global genetic dataset, we confirm that RSV-A has prevailed over RSV-B in the post-pandemic period, consistent with a higher R for RSV-A. With new RSV infant monoclonals and maternal and elderly vaccines becoming widely available, these results may have important implications for understanding intervention effectiveness in the context of disrupted subtype dynamics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196647 | PMC |
| http://dx.doi.org/10.1038/s41598-024-64624-1 | DOI Listing |
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