The effects of the antiaggregant substance ticlopidine and of the anticoagulant acenocoumarol on patency rates of aorto-coronary bypass grafts were compared in a prospective randomized trial. Ticlopidine, 250 mg b.i.d. was administered orally from the first postoperative day till angiography, while anticoagulation with acenocoumarol was initiated on the second to third postoperative day. Side-effects of ticlopidine were rare and patient management with the standard dosage of this drug was easier than oral anticoagulation. From an initial group of 166 randomized patients 149 completed the trial by coronary angiography three months postoperatively. The 78 patients in the ticlopidine group showed a compliance of 85%. The average prothrombin time in the 71 patients receiving acenocoumarol was 26.9%. Detailed statistical analysis of the two study groups revealed no reason to doubt the correctness of randomization. Coronary angiography showed an average patency rate per patient of 84% with ticlopidine and of 82% with acenocoumarol. This and various other measures of graft occlusion did not reveal any substantial difference in graft patency of patients receiving ticlopidine or acenocoumarol. It is concluded that ticlopidine may well be used instead of anticoagulants for prevention of postoperative occlusion of aorto-coronary bypass grafts.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/oxfordjournals.eurheartj.a061831 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- - Mitral regurgitation (MR) is the second most common heart valve disease, and severe cases often require surgical intervention, though high-risk patients may need alternative treatments like transcatheter edge-to-edge valve repair or the Tendyne valve.
- - The Tendyne valve, which can be implanted without traditional surgery, showed promising results: 93.2% of patients had no MR after treatment, and heart failure hospitalizations significantly decreased post-surgery.
- - An economic analysis indicated that using the Tendyne valve is cost-effective compared to medications, with a favorable cost per quality-adjusted life year, and around 60 patients annually could benefit from this treatment in Poland.
Intraoperative intra-aortic balloon pump insertion: step by step.
Multimed Man Cardiothorac Surg
October 2024
Department of Cardiac Surgery, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB SANT PAU), Barcelona, Spain.
A 76-year-old patient with non-ST elevation myocardial infarction was admitted to our hospital. Coronary angiography revealed significant left main and two-vessel coronary artery disease. Preoperative testing indicated severe left ventricular dysfunction.
View Article and Find Full Text PDFSequential composite BIMA grafting for 3v-CAD: factors that predict successful outcome of the one-inflow and two-inflow revascularization techniques.
Gen Thorac Cardiovasc Surg
October 2024
Department of Cardiac Surgery, Cardiac Center, Rotenburg an Der Fulda, Germany.
Objective: The effect of one-inflow and two-inflow coronary surgical revascularization techniques inclosing skeletonized double mammary artery (BIMA) as T-graft on outcome is studied.
Methods: Early ad mid-term outcome of complete BIMA revascularization (C-T-BIMA) versus left-sided BIMA with right-sided aorto-coronary bypass (L-T-BIMA + R-CABG) is quantified and analyzed by multivariate logistic regression, Cox-regression, and Kaplan-Meier analysis in a series of 204 consecutive patients treated for triple-vessel coronary disease (3v-CAD).
Results: The L-T-BIMA + R-CABG technique (n = 104) enables higher number of total (4.
Major adverse cardiovascular events related to phosphodiesterase 5 inhibitors: analysis of real-life data from Eudra-Vigilance database.
Minerva Urol Nephrol
April 2024
Sant'Andrea Hospital, Sapienza University, Rome, Italy.
Background: Phosphodiesterase 5 inhibitors (PDE5i) are the standard medical treatment for erectile dysfunction. Aim of our study was to evaluate the rate of major adverse cardiovascular events (MACE) reported during PDE5i treatment based on Eudra-Vigilance (EV) reports.
Methods: EV database is the system for managing and analyzing data on suspected adverse reactions to medicines which have been authorized or being studied in clinical trials in the European Economic Area.
Tertiary syphilis and cardiovascular disease: the united triad: case report.
Eur Heart J Case Rep
March 2024
Cardiology Department, CHU Mohammed VI, Route de Rabat Km 17 BP 398, Gzinaya, Tangier, Morocco.
Background: Syphilis, owing to its natural course, can lead to long-term damage to the aortic valve, such as insufficiency and rarely stenosis, ostial coronary stenosis, and syphilitic aortitis. Cardiovascular involvement alongside neurological involvement dominates the prognosis. This should no longer be seen, thanks to awareness and prevention programmes, medical treatment, and antibiotics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!