Study Objectives: We evaluated the risk of traumatic injury in patients with narcolepsy compared to the general population.
Methods: We conducted a population-based matched cohort study using a Japanese health insurance claims database. For each patient with narcolepsy, up to 5 individuals from the general population without narcolepsy were matched by variables such as sex, age, and cohort entry month. The primary outcome was traumatic injury, and the secondary outcome was fracture. The study population was followed for up to 5 years from the cohort entry date. We estimated crude incidence rates, adjusted incidence rate differences, adjusted hazard ratios, and their 95% confidence intervals (CIs) for study outcomes using crude and multivariable Poisson and Cox regression models.
Results: We included 2,451 patients with narcolepsy (mean age, 30.3 years; male, 58.0%) and 10,591 matched individuals (mean age, 30.6 years; male, 58.4%). Crude incidence rate of traumatic injury was 11.4 per 100 person-years for patients with narcolepsy compared with 6.2 per 100 person-years for matched individuals (adjusted incidence rate difference, 6.2 excess events per 100 person-years [95% CI, 4.9-7.4]; adjusted hazard ratio, 1.8 [95% CI, 1.5-2.2]). Crude incidence rate of fracture was 2.3 per 100 person-years for patients with narcolepsy compared with 1.3 per 100 person-years for matched individuals (adjusted incidence rate difference, 1.2 excess events per 100 person-years [95% CI, 0.7-1.7]; adjusted hazard ratio, 1.7 [95% CI, 1.4-2.1]).
Conclusions: Narcolepsy was associated with increased risk of traumatic injury. For patients with narcolepsy, optimized approaches to injury prevention should be considered.
Citation: Zheng Y, Fukasawa T, Masuda S, Takeuchi M, Kawakami K. Narcolepsy and risk of traumatic injury: a population-based matched cohort study. 2024;20(10):1657-1662.
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http://dx.doi.org/10.5664/jcsm.11236 | DOI Listing |
J Physiol
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Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Knee osteoarthritis contributes substantially to worldwide disability. Post-traumatic osteoarthritis (PTOA) develops secondary to joint injury, such as ligament rupture, and there is increasing evidence suggesting a key role for inflammation in the aetiology of PTOA and associated functional deficits. Colony stimulating factor 1 receptor (CSF1-R) has been implicated in the pathogenesis of musculoskeletal degeneration following anterior cruciate ligament (ACL) injury.
View Article and Find Full Text PDFBiomed Eng Online
December 2024
Department of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, 15614, Iran.
Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This can lead to a range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, pericardial complications, and vascular toxicity. Strategies to mitigate chemotherapy-induced cardiotoxicity may include the use of cardioprotective agents (e.
View Article and Find Full Text PDFBMC Surg
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Department of Hand (Micro) Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Purpose: Achieving and maintaining an optimal reduction in partially or fully displaced intra-articular fractures, specifically Type C distal radius fractures, can present challenges. This study aims to retrospectively evaluate and summarize a method utilizing multi-directional temporary Kapandji technique in combination with the volar locking plate fixation for these fractures.
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Department of Endocrinology and Metabolism, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518033, China.
BMC Surg
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Department of General Surgery, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian, 350025, P.R. China.
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