Penumbral imaging is a technique used in plasma diagnostics in which a radiation source shines through one or more large apertures onto a detector. To interpret a penumbral image, one must reconstruct it to recover the original source. The inferred source always has some error due to noise in the image and uncertainty in the instrument geometry. Interpreting the inferred source thus requires quantification of that inference's uncertainty. Markov chain Monte Carlo algorithms have been used to quantify uncertainty for similar problems but have never been used for the inference of the shape of an image. Because of this, there are no commonly accepted ways of visualizing uncertainty in two-dimensional data. This paper demonstrates the application of the Hamiltonian Monte Carlo algorithm to the reconstruction of penumbral images of fusion implosions and presents ways to visualize the uncertainty in the reconstructed source. This methodology enables more rigorous analysis of penumbral images than has been done in the past.
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http://dx.doi.org/10.1063/5.0214641 | DOI Listing |
Stroke
January 2025
Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China (X.C., L.H., Y.L., Yiran Zhang, X.L., S.L., L.Y., Q.D.).
Background: Whether it is effective and safe to extend the time window of intravenous thrombolysis up to 24 hours after the last known well is unknown. We aimed to determine the efficacy and safety of tenecteplase in Chinese patients with acute ischemic stroke due to large/medium vessel occlusion within an extended time window.
Methods: Patients with ischemic stroke presenting 4.
Age Ageing
November 2024
Department of Clinical Neurosciences, University of Cambridge, R3 Clinical Neurosciences (Box 83) Addenbrooke's Hospital Hills Road, Cambridge CB2 0QQ, UK.
Background: Frailty-the loss of physiological reserve to withstand a stressor event-is associated with poorer outcomes following acute stroke reperfusion therapies. However, the mechanisms underlying this relationship are poorly understood. This study investigated the association between frailty and penumbral volumes in hyperacute ischemic stroke.
View Article and Find Full Text PDFJ Neurol Sci
January 2025
Department of Neurology - Division of Vascular Neurology, Stanford Hospital, Palo Alto, CA, United States of America. Electronic address:
Background: Recent literature suggests circadian rhythm influences cerebral perfusion parameters in adults experiencing an acute large vessel occlusion, but this has never been investigated in the pediatric and young adult populations.
Methods: We queried the United States RAPID Insights database (10/05/2018-09/29/2023) for unique patients between 2 and 25 years with computed tomography perfusion (CTP). Included scans had a minimum ischemic core volume (rCBF <30 %) of >0 cc and a Tmax volume of >0 cc.
Stroke
January 2025
Department of Diagnostic and Interventional Neuroradiology (G.B., M.M., M.B., H.K., L.W., C.H., J.F., L.M.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Radiol Phys Technol
November 2024
Department of Radiological Technology, Faculty of Health Science, Juntendo University, Tokyo, Japan.
Uncertainties in the steps of external beam radiotherapy (EBRT) affect patient outcomes. However, few studies have investigated major contributors to these uncertainties. This study investigated factors contributing to reducing uncertainty in delivering a dose to a target volume.
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