AI Article Synopsis

  • Therapeutic vaccinations aim to prevent cancer by triggering immune responses against specific tumor-associated antigens (TAA) found in cancer cells.
  • These vaccinations primarily focus on activating CD8 T lymphocytes, which play a crucial role in suppressing tumor growth by releasing cytokines.
  • The review discusses how peptide-based vaccines enhance the production of important cytokines like IFN-γ, TNF-α, IL-2, and IL-12, and also examines the mechanisms of T cell activation and dysfunction.

Article Abstract

Therapeutic vaccinations are designed to prevent cancer by inducing immune responses against tumor antigens. in cancer cells, tumor-associated antigens (TAA) or tumor-specific (mutated) derived peptides are presented within the clefts of main histocompatibility complex (MHC) class I or class II molecules, they either activate cytotoxic T-lymphocytes (CTLs), CD4 T or CD8 T lymphocytes, which release cytokines that can suppress tumor cells growth. In cancer immunotherapies, CD8 T lymphocytes are a major mediator of tumor repression. The effect of peptide-based vaccinations on cytokines in the activating CD8 T cell against targeted tumor antigens is the subject of this review. It is believed that peptide-based vaccines increased IFN-γ, TNF-α, IL-2, and IL-12, secreting CTL line by interacting with dendritic cell (DC), supposed to stimulate immune system. Additionally, mechanisms of CTL activation and dysfunction were also studied. According to most of the data resulted from in vivo and in vitro research works, it is assumed that peptide-based vaccines increased IFN-γ, TNF-α, IL-2, and IL-12.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190603PMC
http://dx.doi.org/10.1016/j.heliyon.2024.e32249DOI Listing

Publication Analysis

Top Keywords

tumor antigens
8
cd8 lymphocytes
8
peptide-based vaccines
8
vaccines increased
8
increased ifn-γ
8
ifn-γ tnf-α
8
tnf-α il-2
8
il-2 il-12
8
pro-inflammatory responses
4
peptide-based
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!