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| http://dx.doi.org/10.1055/s-0044-1781469 | DOI Listing |
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Violaceoid F induces nuclear translocation of FOXO3a by inhibiting CRM1 via a novel mechanism and suppresses HeLa cell growth.
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December 2024
Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science, Wako, Japan.
FOXO3a is a transcription factor involved in cell growth inhibition and apoptosis. FOXO3a is localized in the cytoplasm in cancer cells, and its nuclear translocation by small molecules is expected to prevent cancer cell growth. In this study, we screened a fungal broth library in HeLa cells using fluorescently labeled FOXO3a and an AI-based imaging system.
View Article and Find Full Text PDFVenous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.
Circ Res
December 2024
Cardiovascular Research Center, Massachusetts General Hospital, Boston. (C.C., P.X., Z.Y., Y.S., E.S.L., J.D.R., M.C.H.).
Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.
View Article and Find Full Text PDFMining and analysis of adverse events associated with aducanumab: a real-world study using FDA adverse event reporting system database.
Expert Opin Drug Saf
December 2024
Zhejiang Academy of Traditional Chinese Medicine, Tongde hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Background: Aducanumab, a monoclonal antibody, received approval for the treatment of Alzheimer's disease in 2021. However, it remains controversial over the security of this drug. In this study, aducanumab-related adverse events (AEs) were evaluated through data mining based on the FDA Adverse Event Reporting System (FAERS) database.
View Article and Find Full Text PDFIdentification of patients with unstable angina based on coronary CT angiography: the application of pericoronary adipose tissue radiomics.
Front Cardiovasc Med
December 2024
Cardiovascular Medicine Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Objective: To explore whether radiomics analysis of pericoronary adipose tissue (PCAT) captured by coronary computed tomography angiography (CCTA) could discriminate unstable angina (UA) from stable angina (SA).
Methods: In this single-center retrospective case-control study, coronary CT images and clinical data from 240 angina patients were collected and analyzed. Patients with unstable angina ( = 120) were well-matched with those having stable angina ( = 120).
Right Thoracoscopic, Robot-Assisted Resection of an Apical Mediastinal C7 Schwannoma.
J Neurol Surg Rep
October 2024
Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Spinal schwannomas are benign, slow-growing tumors originating from Schwann cells, constituting 25 to 30% of primary spinal neoplasms and most frequently arise from sensory nerve roots in the cervical or thoracic spine. 1 2 3 Although generally nonaggressive, their growth can result in significant neurological deficits due to compression of surrounding structures such as the spinal cord or nerve roots. 4 5 Patients commonly present with localized pain, muscle weakness, and sensory disturbances.
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