Gender differences in union formation and sexual initiation in sub-Saharan Africa remain poorly documented, in large part due to a scarcity of research on the transition to adulthood among men. We adopt a novel perspective on this topic by examining in the ages at first union and sex in 24 countries, focusing on measures of central tendency and dispersion. Gender differences in age at first union decreased, driven by postponement among women with relatively late union formation. Yet, due to concurrent persistence of early unions among a sizable portion of women's populations, within-country heterogeneity in ages at first union increased substantially among women. Thus, although forces responsible for earlier union formation among women than men are weakening, these changes affect population strata unequally. Gender differences in age at first sex decreased to a lesser extent, but in some countries, they disappeared or reversed, uncovering a shift in the relationship between gender and timing of sexual initiation. Changes in union formation and sexual initiation are more heterogeneous across countries among men than women, indicating that these processes among men are more context specific. We show importance of studying men's behavior and exploring heterogeneity in union formation and sexual initiation both within and between populations of women and men.
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http://dx.doi.org/10.1111/padr.12405 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
SOX9 is a crucial transcriptional regulator of cartilage development and homeostasis. Dysregulation of is associated with a wide spectrum of skeletal disorders, including campomelic dysplasia, acampomelic campomelic dysplasia, and scoliosis. Yet how variants contribute to the spectrum of axial skeletal disorders is not well understood.
View Article and Find Full Text PDFFEBS J
January 2025
Department of Orthopedics, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Osteosarcoma, a malignant bone tumor that occurs in adolescents, proliferates and is prone to pulmonary metastasis. Osteosarcoma is characterized by high genotypic heterogeneity, making it difficult to identify reliable anti-osteosarcoma targets. The genotype of osteosarcoma may be highly dynamic, but its high dependence on energy remains constant.
View Article and Find Full Text PDFMetabolomics
January 2025
Laboratory of Organic Chemistry, Wageningen University & Research, 6708 WE, Wageningen, the Netherlands.
Introduction And Objective: Rumex sanguineus, a traditional medicinal plant of the Polygonaceae family, is gaining popularity as an edible resource. However, despite its historical and nutritional significance, its chemical composition remains poorly understood. To deepen the understanding of the of Rumex sanguineus composition, an in-depth analysis using non-targeted, mass spectrometry-based metabolomics was performed.
View Article and Find Full Text PDFToxins (Basel)
December 2024
Laboratory of Plant Pathology, Department of Crop Science, Agricultural University of Athens, 118 55 Athens, Greece.
is considered one of the main fungi responsible for black and sour rot in grapes, as well as the production of the carcinogenic mycotoxin ochratoxin A. The global regulatory methyltransferase protein controls the production of various secondary metabolites in species, as well as influences sexual and asexual reproduction and morphology. The goal of this study was to investigate the role of the regulatory gene in physiology, virulence, and ochratoxin A (OTA) production by deleting this gene from the genome of a wild-type strain.
View Article and Find Full Text PDFJ Funct Biomater
January 2025
Department of Pharmaceutical Science, University of Perugia, 06123 Perugia, Italy.
Magnesium alloys are promising biomaterials to be used as temporary implants due to their biocompatibility and biodegradability. The main limitation in the use of these alloys is their rapid biodegradation. Moreover, the risk of microbial infections, often following the implant surgery and hard to eradicate, is another challenge.
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