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Proteomics of for a Deeper Understanding of Lead (Pb) Metal Bioremediation. | LitMetric

Proteomics of for a Deeper Understanding of Lead (Pb) Metal Bioremediation.

ACS Omega

Proteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, P O Box 2925 98 Riyadh 11461, Saudi Arabia.

Published: June 2024

AI Article Synopsis

  • A filamentous fungus has shown potential for cleaning up lead-contaminated environments due to its ability to tolerate and accumulate lead, along with its fast growth.
  • This study explored how lead stress affects protein changes in the fungus using advanced techniques like 2D-DIGE and MALDI-TOF-MS, identifying 43 significant proteins involved in various functions.
  • This research represents a pioneering effort in understanding fungal responses to lead stress, potentially leading to the creation of innovative markers for bioremediation processes.

Article Abstract

(), a ubiquitous filamentous fungus, has demonstrated remarkable potential in the bioremediation of lead-contaminated environments. Its inherent tolerance and bioaccumulation capacity for lead (Pb), coupled with its relatively rapid growth rate, make it an attractive candidate for bioremediation applications. This study aims to identify the proteomic changes in induced by Pb metal stress and unravel the roles of identified proteins in molecular mechanisms and cellular responses. Untargeted proteomic analysis was carried out using a two-dimensional difference in gel electrophoresis (2D-DIGE) coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). This study reported the identification of 43 statistically significant proteins (24 upregulated and 19 downregulated, ANOVA, ≤ 0.05; fold change ≥1.5) in as a consequence of Pb treatment. Proteins were grouped according to their function into 18 groups from which 13 proteins were related to metabolism, 11 were related to cellular process and signaling, and 19 proteins were related to information storage and processing. The current study is considered the first report about the proteomics study of under Pb stress conditions, where upregulated proteins could better explain the mechanism of tolerance and Pb toxicity removal. Our research has provided a thorough understanding of the molecular and cellular processes involved in fungal-metal interactions, paving the way for the development of innovative molecular markers for heavy metal myco-remediation. To the best of our knowledge, this study of provides valuable insights toward growing research in comprehending the metal-microbe interactions. This will facilitate development of novel molecular markers for metal bioremediation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190926PMC
http://dx.doi.org/10.1021/acsomega.4c02006DOI Listing

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