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Piceatannol enhances hyaluronic acid synthesis through SIRT1-Mediated HAS2 upregulation in human dermal fibroblasts. | LitMetric
Dermal fibroblasts play a crucial role in skin structure and function by producing hyaluronic acid. Piceatannol (PIC), a polyphenol abundant in passion fruit seeds, has been reported to activate sirtuin 1 (SIRT1). Clinical trials have demonstrated that PIC intake improves skin moisture and maintains skin elasticity, yet the underlying mechanism remains unclear. This study aimed to investigate the effects of PIC on hyaluronic acid biosynthesis and the involvement of SIRT1 in this process. Human dermal fibroblast Hs68 cells were stimulated with PIC, and the expression levels of and , key enzymes in hyaluronic acid biosynthesis, as well as expression, were assessed using quantitative real-time PCR. Additionally, the role of in the hyaluronic acid biosynthesis pathway during PIC stimulation was examined using a SIRT1 inhibitor. The results demonstrated that PIC increased expression while decreasing expression in human dermal fibroblasts. Furthermore, PIC enhanced expression, and pre-treatment with a SIRT1 inhibitor mitigated PIC-induced upregulation of , suggesting that PIC promotes hyaluronic acid synthesis by inducing . These findings suggest that PIC could serve as a beneficial food ingredient, enhancing skin structure and function by promoting hyaluronic acid biosynthesis via induction.
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