is an arachnid genus comprising several species in the United States, popularly known as brown recluse spiders. The venom is cytotoxic, complex, and has a mixture of many proteins, some of which function as proteases. Envenomation can cause necrotic skin lesions that may become extensive and take many months to heal. Even more rarely, venom may cause systemic effects, leading to widespread hemolysis, coagulopathy, and death. These symptoms typically occur rapidly within 24-48 hours following the bite. We describe a rare case of a 44-year-old male with fatal systemic loxoscelism with orbital compartment syndrome requiring emergent lateral canthotomy and cantholysis.
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http://dx.doi.org/10.7759/cureus.60943 | DOI Listing |
PLoS One
October 2024
Molecular Ecology Group, Water Research Institute, National Research Council of Italy, Verbania Pallanza, Italy.
Fear of spiders is a widespread condition often disproportionate to the actual danger spiders pose to humans. Likely rooted in evolutionary history, fear of spiders might also have a cultural component. Recent studies have shown that a significant fraction of spider-related media reports are misleading and sensationalistic.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba 81530-900, PR, Brazil. Electronic address:
Spiders of Loxosceles genus, or Brown spiders produce a potent venom with minimal volume and protein content. Among its toxins, phospholipases D (PLDs) are notable for causing primary local and systemic manifestations observed following envenomation. They degrade cellular phospholipids, mainly sphingomyelin and lysophosphatidylcholine.
View Article and Find Full Text PDFCureus
July 2024
Department of Emergency Medicine, Ascension Health, Murfreesboro, USA.
Acta Trop
October 2024
Department of Cell Biology, Federal University of Paraná (UFPR), Curitiba, 81530-900, PR, Brazil. Electronic address:
Loxoscelism is the pathological condition triggered by a brown spider bite. The venom of these spiders is rich in phospholipases D (PLDs), which can induce virtually all local and systemic manifestations. Recombinant mutated PLDs from clinically relevant Loxosceles species in South America have been investigated as potential antigens to develop novel therapeutic strategies for loxoscelism.
View Article and Find Full Text PDFHeliyon
July 2024
Laboratorio de Estructura Biomolecular, Centro de Investigación en Alimentación y Desarrollo, A. C., Hermosillo, Sonora, Mexico.
spp. spiders can cause serious public health issues. Chemical control is commonly used, leading to health and environmental problems.
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