AI Article Synopsis
- A new method was created to combine alkynylphenols with epoxides and elemental sulfur or selenium using a copper catalyst, resulting in a unique 3-chalcogen-benzofuran structure.
- This process operates as a domino reaction, meaning it occurs in one go without needing to isolate or purify intermediates.
- The method works well at room temperature, allowing for various sensitive functional groups and producing good yields of chalcogenation derivatives.
Article Abstract
A novel copper-catalyzed cyclization/chalcogenation of -alkynylphenols with epoxides and elemental S/Se was developed for the synthesis of a 3-chalcogen-benzofuran architecture in a domino process with no intermediate isolation or purification. Various sensitive functional groups were compatible at room temperature and furnished chalcogenation derivatives in moderate to good yields.
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| http://dx.doi.org/10.1021/acs.joc.4c00077 | DOI Listing |
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