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Sulfoxidation of pyrimidine thioate derivatives and study their biological activities.
Sci Rep
January 2025
Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
In a quest to innovate biologically active molecules, the benzoylation of 4,6-dimethylpyrimidine-2-thiol hydrochloride (1) with benzoyl chloride derivatives was employed to produce a series of pyrimidine benzothioate derivatives (2-5). Subsequent sulfoxidation of these derivatives (2-5) using hydrogen peroxide and glacial acetic acid yielded a diverse array of pyrimidine sulfonyl methanone derivatives (6-9). In parallel, the sulfoxidation of pyrimidine sulfonothioates (10-12) yielded sulfonyl sulfonyl pyrimidines (13-15), originating from the condensation of compound 1 with sulfonyl chloride derivatives.
View Article and Find Full Text PDFEvaluation of Benzene Presence and Formation in Benzoyl Peroxide Drug Products.
J Invest Dermatol
October 2024
Valisure, LLC, New Haven, Connecticut, USA; Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Long Island, New York, USA.
Article Synopsis
- - Benzoyl peroxide (BPO), commonly used in acne treatments, can degrade into benzene, a harmful carcinogen, especially when stored or used at high temperatures.
- - A study detected varying levels of benzene (0.16 to 35.30 ppm) in 111 over-the-counter BPO products when kept at room temperature, while a prescription version showed none at low temperatures but significant benzene at high temperatures.
- - Experiments revealed that using BPO on skin models can lead to detectable benzene levels in the air, especially under UV light, highlighting health risks from benzene exposure regardless of the initial concentration in the products.
No association of benzoyl peroxide use with acute myeloid leukemia and hematologic malignancies in a multi-center retrospective study.
J Am Acad Dermatol
December 2024
Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:
Benzoyl Peroxide, Benzene, and Lots of Unanswered Questions: Where Are We Now?
Cutis
July 2024
JDR Dermatology Research, Las Vegas, Nevada; Advanced Dermatology & Cosmetic Surgery, Maitland, Florida; and Touro University Nevada, Henderson.
Benzoyl peroxide for acne treatment is not associated with an increased risk of malignancy: A retrospective cohort study.
J Am Acad Dermatol
November 2024
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:
Article Synopsis
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