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An IS element-driven antisense RNA attenuates the expression of serotype 2 fimbriae and the cytotoxicity of .
Emerg Microbes Infect
January 2025
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, F-59000 Lille, France.
Insertion sequences (IS) represent mobile genetic elements that have been shown to be associated with bacterial evolution and adaptation due to their effects on genome plasticity. In , the causative agent of whooping cough, the numerous IS elements induce genomic rearrangements and contribute to the diversity of the global population. Previously, we have shown that the majority of IS-specific endogenous promoters induce the synthesis of alternative transcripts and thereby affect the transcriptional landscape of .
View Article and Find Full Text PDFVaccine Acceptance Among Pregnant Women in Israel During COVID-19: Influences and Decision-Making Factors.
Vaccines (Basel)
December 2024
The Shamir Medical Center (Assaf Harofeh), Rishon LeZion, 4 Icet, Zrifin 7033001, Israel.
In response to the COVID-19 pandemic, Israel prioritized pregnant women for vaccination, recognizing them as a high-risk group. This study aims to explore factors influencing the acceptance of Influenza, Pertussis (T-dap), and COVID-19 vaccines among pregnant women, focusing on attitudes, social norms, perceived control, and risk perceptions. Additionally, the study compares acceptance patterns between traditional vaccines and the newer COVID-19 vaccine.
View Article and Find Full Text PDFEpidemiological characteristics and prediction model construction of hand, foot and mouth disease in Quzhou City, China, 2005-2023.
Front Public Health
January 2025
Department of Immunity, Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang, China.
Background: HFMD is a common infectious disease that is prevalent worldwide. In many provinces in China, there have been outbreaks and epidemics of whooping cough, posing a threat to public health.
Purpose: It is crucial to grasp the epidemiological characteristics of HFMD in Quzhou and establish a prediction model for HFMD to lay the foundation for early warning of HFMD.
Learning the fitness dynamics of pathogens from phylogenies.
Nature
January 2025
Department of Genetics, University of Cambridge, Cambridge, UK.
The dynamics of the genetic diversity of pathogens, including the emergence of lineages with increased fitness, is a foundational concept of disease ecology with key public-health implications. However, the identification of such lineages and estimation of associated fitness remain challenging, and is rarely done outside densely sampled systems. Here we present phylowave, a scalable approach that summarizes changes in population composition in phylogenetic trees, enabling the automatic detection of lineages based on shared fitness and evolutionary relationships.
View Article and Find Full Text PDFReal-Life Insights into Pertussis Diagnosis: High Yield of PCR Testing and Clinical Outcomes-An Emerging Old Enemy or Just a Sign of PCR Times?
J Pers Med
November 2024
Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, 41500 Larissa, Greece.
Pertussis remains a significant public health concern despite effective vaccines due to diagnostic challenges and symptom overlap with other respiratory infections. This study assesses the prevalence of using advanced polymerase chain reaction (PCR) testing and examines the clinical outcomes over a one-month follow-up. We conducted a cross-sectional study at the University Hospital of Larissa, Greece, from April to June 2024, collecting 532 nasopharyngeal swabs from patients with respiratory symptoms.
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