AI Article Synopsis
- Physical activity and athletic performance are influenced by a mix of environmental and genetic factors, with recent advancements in genomics identifying various DNA variants linked to these traits.
- These genetic variants are being used in studies to understand how physical activity affects health outcomes and to investigate relationships between genetics and athlete performance.
- As of September 2023, research has identified 149 variants related to physical activity traits and 253 variants associated with different athlete statuses, covering endurance, power, and strength.
Article Abstract
Physical activity and athletic performance are complex phenotypes influenced by environmental and genetic factors. Recent advances in lifestyle and behavioral genomics led to the discovery of dozens of DNA polymorphisms (variants) associated with physical activity and allowed to use them as genetic instruments in Mendelian randomization studies for identifying the causal links between physical activity and health outcomes. On the other hand, exercise and sports genomics studies are focused on the search for genetic variants associated with athlete status, sports injuries and individual responses to training and supplement use. In this review, the findings of studies investigating genetic markers and their associations with physical activity and athlete status are reported. As of the end of September 2023, a total of 149 variants have been associated with various physical activity traits (of which 42 variants are genome-wide significant) and 253 variants have been linked to athlete status (115 endurance-related, 96 power-related, and 42 strength-related).
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| http://dx.doi.org/10.1016/bs.adgen.2024.01.001 | DOI Listing |
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