Background: Despite its success in the mechanical characterization of biological tissues, magnetic resonance elastography (MRE) uses ill-posed wave inversions to estimate tissue stiffness. 1-Norm has been recently introduced as a mathematical measure for the scattering of mechanical waves due to inhomogeneities based on an analysis of the delineated contours of wave displacement.
Purpose: To investigate 1-Norm as an MRE-based quantitative biomarker of mechanical inhomogeneities arising from microscopic structural tissue alterations caused by the freeze-thaw cycle (FTC) or Alzheimer's disease (AD).
Methods: In this proof-of-concept study, we prospectively investigated excised porcine kidney (n = 6), liver (n = 6), and muscle (n = 6) before vs. after the FTC at 500-2000 Hz and excised murine brain of healthy controls (n = 3) vs. 5xFAD species with AD (n = 3) at 1200-1800 Hz using 0.5 T tabletop MRE. 1-Norm analysis was compared with conventional wave inversion.
Results: While the FTC reduced both stiffness and inhomogeneity in kidney, liver, and muscle tissue, AD led to lower brain stiffness but more pronounced mechanical inhomogeneity.
Conclusion: Our preliminary results show that 1-Norm is sensitive to tissue mechanical inhomogeneity due to FTC and AD without relying on ill-posed wave inversion techniques. 1-Norm has the potential to be used as an MRE-based diagnostic biomarker independent of stiffness to characterize abnormal conditions that involve changes in tissue mechanical inhomogeneity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jmbbm.2024.106636 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Sample Storage Time and Temperature on the Stability of Respiratory Viruses and Enteric Viruses in Wastewater.
Microorganisms
November 2024
Public Health Laboratory, Alberta Precision Laboratories, Edmonton, AB T6G 2J2, Canada.
Wastewater-based surveillance (WBS) has been widely used to track SARS-CoV-2 as well as many other viruses in communities during the COVID pandemic and post-pandemic. However, it is still not clear how temperature and storage time would influence the stability of viruses in wastewater. In this study, we assessed the stability of SARS-CoV-2, pepper mild mottle virus (PMMoV), influenza viruses A (IAV) and B (IBV), respiratory syncytial virus (RSV), and enteric viruses in raw wastewater stored at room temperature, 4 °C, and -20 °C for 3 and 6 days.
View Article and Find Full Text PDFCrack Sealing in Concrete with Biogrout: Sustainable Approach to Enhancing Mechanical Strength and Water Resistance.
Materials (Basel)
December 2024
School of Civil and Transportation Engineering, Hebei University of Technology, Tianjin 300401, China.
Concrete, as the most widely used construction material globally, is prone to cracking under the influence of external factors such as mechanical loads, temperature fluctuations, chemical corrosion, and freeze-thaw cycles. Traditional concrete crack repair methods, such as epoxy resins and polymer mortars, often suffer from a limited permeability, poor compatibility with substrates, and insufficient long-term durability. Microbial biogrouting technology, leveraging microbial-induced calcium carbonate precipitation (MICP), has emerged as a promising alternative for crack sealing.
View Article and Find Full Text PDFStudy on the Dynamic Fracture Properties of Defective Basalt Fiber Concrete Materials Under a Freeze-Thaw Environment.
Materials (Basel)
December 2024
Department of Mining Engineering, School of Environment and Resources, Southwest University of Science and Technology, Mianyang 621010, China.
This study examines the crack resistance of basalt-fiber-reinforced concrete (BFRC) materials subjected to freeze-thaw cycles (FTCs). We utilized a φ50 mm Split Hopkinson Pressure Bar (SHPB) apparatus alongside numerical simulations to carry out impact compression tests at a velocity of 5 m/s on BFRC specimens that experienced 0, 10, 20, and 30 FTCs. Additionally, we investigated the effects of basalt fiber (BF) orientation position and length on stress intensity factors.
View Article and Find Full Text PDFNondestructive Monitoring of Textile-Reinforced Cementitious Composites Subjected to Freeze-Thaw Cycles.
Materials (Basel)
December 2024
Department of Mechanics of Materials and Constructions, Faculty of Engineering, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Cementitious materials are susceptible to damage not only from mechanical loading, but also from environmental (physical, chemical, and biological) factors. For Textile-Reinforced Cementitious (TRC) composites, durability poses a significant challenge, and a reliable method to assess long-term performance is still lacking. Among various durability attacks, freeze-thaw can induce internal cracking within the cementitious matrix, and weaken the textile-matrix bond.
View Article and Find Full Text PDFRelationship Between the Carbonation Depth and Microstructure of Concrete Under Freeze-Thaw Conditions.
Materials (Basel)
December 2024
College of Hydraulic and Environmental Engineering, Three Gorges University, Yichang 443000, China.
Concrete structures in cold regions are affected by freeze-thaw cycles (FTCs) and carbonation, which lead to the premature failure of concrete structures. The carbonation depth, relative dynamic elastic modulus (RDEM), compressive strength, porosity, and pore size distribution of concrete under FTC conditions were tested through an accelerated carbonation experiment to study the carbonation performance evolution. The freeze-thaw effect mechanism on concrete carbonation was further analyzed via the obtained relationship between carbonation depth and pore structure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!