Disulfiram (DSF) metabolites exhibit antitumor properties when bound to Cu. This combination also promotes the generation of reactive oxygen species (ROS), ultimately leading to tumor cell death. In this study, CuO served as a carrier for DSF, forming a dual-drug delivery system with Cu and DSF encapsulated in polydopamine (PDA). In the final delivery system, CuO (DSF-CuO@PDA) was hydrolyzed at the tumor site, releasing both Cu and HO. Cu reacts with DSF metabolites to form Bis(diethyldithiocarbamate)-Cu (CuET), which triggers a Fenton-like reaction that generates ROS. Chemotherapy and chemodynamic therapy exhibited significant tumor-suppressive capabilities, with an inhibition rate of 61 %. In addition, the DSF-CuO@PDA complex demonstrated superlative tumor-targeting ability and biocompatibility.
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