AI Article Synopsis
- Rett syndrome is a neurodevelopmental disorder that often leads to scoliosis as a common orthopedic issue.
- This study investigates which factors can predict the rapid worsening of scoliosis in patients with Rett syndrome to help create models for future predictions.
- Key predictors for rapid progression identified include the patient's age at the start of the study, initial Cobb angle measurements, and the presence of epilepsy.
Article Abstract
Rett syndrome is a neurodevelopmental disorder in which scoliosis is a common orthopedic complication. This explorative study aims to identify predictors for rapid progression of scoliosis in Rett syndrome to enable variable selection for future prediction model development. A univariable logistic regression model was used to identify variables that discriminate between individuals with and without rapid progression of scoliosis (>10Cobb angle/6 months) based on multi-center data. Predictors were identified using univariable logistic regression with OR (95% CI) and AUC (95% CI). Age at inclusion, Cobb angle at baseline and epilepsy have the highest discriminative ability for rapid progression of scoliosis in Rett syndrome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/17518423.2024.2365794 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!