[Successful treatment of Lepiota brunneoincarnata poisoning in Argentina].

Medicina (B Aires)

Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Buenos Aires, Argentina. E-mail:

Published: June 2024

Mushrooms containing amatoxins generate the highest number of fatal mycete poisonings on the planet. These toxins are produced not only by Amanita species, such as the well-known Amanita phalloides, but also by other genera, including Lepiota. In this work we report the treatment of a 51-year-old male patient weighing 79 kg who was referred to the hospital after 36 h of ingesting mushrooms. The mushrooms were identified as Lepiota brunneoincarnata, found for the first time in Argentina. The patient presented general malaise, nausea and repeated vomiting, abdominal pain, and diarrhea. Thanks to a quick anamnesis and early and accurate identification of the fungus, he was administered a nasogastric tube and serial activated charcoal. Additionally, N-acetylcysteine, phytomenadione and penicillin G EV were administered. The patient was discharged 11 days after admission. This case highlights the importance of obtaining a correct and sufficient anamnesis on fungi, enabling rapid analysis of them, and initiation of timely treatment for intoxication. Once again, the importance of having Toxicological Information and Advice Centers (CIAT) with experience and knowledge of micetisms is demonstrated.

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[Successful treatment of Lepiota brunneoincarnata poisoning in Argentina].

Medicina (B Aires)

June 2024

Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Buenos Aires, Argentina. E-mail:

Mushrooms containing amatoxins generate the highest number of fatal mycete poisonings on the planet. These toxins are produced not only by Amanita species, such as the well-known Amanita phalloides, but also by other genera, including Lepiota. In this work we report the treatment of a 51-year-old male patient weighing 79 kg who was referred to the hospital after 36 h of ingesting mushrooms.

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Background: In spite of the scientific evidence supporting health advantages of mushrooms, some of them are seriously poisonous. The clinical picture of mushroom intoxication ranges from minor gastrointestinal symptoms to organ failure, such as liver failure and death.

Method: We provided demographics, clinicopathological characteristics, applied treatments, and outcomes of mushroom poisoning by Lepiota species in a series of 18 cases that were referred from Kermanshah and Lorestan provinces to Abu-Ali-Sina Hospital, Shiraz, Iran.

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Article Synopsis
  • Lepiota brunneoincarnata is a toxic mushroom that can cause severe liver and kidney damage, with two cases reported in a mother and son from Yunnan, China.
  • Both patients showed gastrointestinal symptoms shortly after eating the mushrooms and were diagnosed with acute liver and kidney injuries after seeking medical help.
  • Treatments included activated charcoal and other medications, leading to one patient's complete recovery, while the other faced ongoing kidney issues, eventually requiring multiple treatments and facing chronic kidney insufficiency months later.
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Article Synopsis
  • Lepiota brunneoincarnata is a toxic mushroom that can cause fatal poisonings, with α-amanitin and β-amanitin being its primary poisonous compounds.
  • A new ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to detect and quantify these toxins in rat plasma quickly and accurately.
  • The method demonstrated high sensitivity and precision, and was successfully used in a study to analyze the toxicokinetics of Lepiota brunneoincarnata after its extracts were given to rats.
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