AI Article Synopsis

  • 5-15% of dermatologic cancers occur in the eyelids, mainly involving basal cell carcinoma, squamous cell carcinoma, and sebaceous cell carcinoma, along with melanoma and Merkel cell carcinoma; risk factors include age, smoking, and UV light exposure.!* -
  • Research on eyelid malignancies is limited but essential since many systemic cancers can first appear as eyelid lesions, indicating the need for early detection and treatment to enhance patient outcomes.!* -
  • Treatment strategies for eyelid cancers include Mohs surgery as the preferred method, along with local excision and various non-surgical options like radiotherapy, cryotherapy, immunotherapy, and topical drugs.!*

Article Abstract

Approximately 5-15% of all dermatologic malignancies manifest in the upper and lower eyelids. The primary types include basal cell carcinoma, squamous cell carcinoma, and sebaceous cell carcinoma, with Merkel cell carcinoma and melanoma following closely behind. Basal cell carcinoma predominantly affects the lower eyelid, yet various other carcinomas, melanomas, metastases, and neoplasms of diverse origins can arise on both upper and lower eyelids. Risk factors such as advanced age, smoking, and notably, exposure to UV light significantly contribute to the development of these eyelid lesions. Despite the increasing incidence, research on dermatologic eyelid malignancies remains limited. However, such study is imperative given that many systemic oncologic malignancies initially present as metastatic eyelid lesions. This paper provides an in-depth exploration of eyelid anatomy, clinical presentation, diagnosis, and treatment management.Key Points: Eyelid metastases represent less than one percent of all eyelid cancers, yet they often serve as the initial indication of an underlying systemic malignancy. Early detection and treatment is crucial in improving prognosis and quality of life for patients. Treatment options encompass a range of modalities, with Mohs surgery as the gold standard for the removal of ocular tumors. Additional treatment options include local excision as well as non-surgical interventions such as radiotherapy, cryotherapy, immunotherapy, and topical medications.

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Source
http://dx.doi.org/10.1007/s00403-024-03163-1DOI Listing

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