AI Article Synopsis
- - The study focuses on how cell adhesion proteins create stable clusters that connect the cell membrane to its surroundings, influenced by the shape of the membrane.
- - Researchers explore the relationship between membrane curvature and protein density, showing that an optimal range of these factors leads to effective clustering of adhesion proteins.
- - The findings contrast with a previous theory on tilt-induced gradient sensing, revealing important distinctions in how these mechanisms operate in the clustering of adhesion proteins.
Article Abstract
Cell adhesion proteins typically form stable clusters that anchor the cell membrane to its environment. Several works have suggested that cell membrane protein clusters can emerge from a local feedback between the membrane curvature and the density of proteins. Here, we investigate the effect of such a curvature-sensing mechanism in the context of cell adhesion proteins. We show how clustering emerges in an intermediate range of adhesion and curvature-sensing strengths. We identify key differences with the tilt-induced gradient sensing mechanism we previously proposed (Lin et al., arXiv:2307.03670).
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| http://dx.doi.org/10.1103/PhysRevE.109.054406 | DOI Listing |
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