AI Article Synopsis

  • Tuberculosis (TB) is a major health threat, being the second leading cause of death from an infectious agent, and long-term TB treatment can cause liver injury known as antituberculosis drug-induced liver injury (ATB-DILI).
  • Researchers analyzed blood samples from 107 individuals, comparing healthy controls and TB patients, some of whom developed ATB-DILI early in treatment while others did not.
  • The study found significant changes in the levels of 77 metabolites related to fatty acids and bile acids in patients with ATB-DILI, suggesting that these metabolic pathways are crucial for understanding the condition's progression.

Article Abstract

Tuberculosis (TB) remains the second leading cause of death from a single infectious agent and long-term medication could lead to antituberculosis drug-induced liver injury (ATB-DILI). We established a prospective longitudinal cohort of ATB-DILI with multiple timepoint blood sampling and used untargeted metabolomics to analyze the metabolic profiles of 107 plasma samples from healthy controls and newly diagnosed TB patients who either developed ATB-DILI within 2 months of anti-TB treatment (ATB-DILI subjects) or completed their treatment without any adverse drug reaction (ATB-Ctrl subjects). The untargeted metabolome revealed that 77 metabolites (of 895 total) were significantly changed with ATB-DILI progression. Among them, levels of multiple fatty acids and bile acids significantly increased over time in ATB-DILI subjects. Meanwhile, metabolites of the same class were highly correlated with each other and pathway analysis indicated both fatty acids metabolism and bile acids metabolism were up-regulated with ATB-DILI progression. The targeted metabolome further validated that 5 fatty acids had prediction capability at the early stage of the disease and 6 bile acids had a better diagnostic performance when ATB-DILI occurred. These findings provide evidence indicating that fatty acids metabolism and bile acids metabolism play a vital role during ATB-DILI progression. Our report adds a dynamic perspective better to understand the pathological process of ATB-DILI in clinical settings.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193241PMC
http://dx.doi.org/10.1186/s12931-024-02837-8DOI Listing

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