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Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity.
PLoS Comput Biol
January 2025
Genesupport, Avenue de Sévelin 18, Lausanne, Switzerland.
Catalysis and specifically autocatalysis are the quintessential building blocks of life. Yet, although autocatalytic networks are necessary, they are not sufficient for the emergence of life-like properties, such as replication and adaptation. The ultimate and potentially fatal threat faced by molecular replicators is parasitism; if the polymerase error rate exceeds a critical threshold, even the fittest molecular species will disappear.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Alzheimer's disease (AD) is classically viewed as a predominantly amnestic syndrome, with other cognitive and neuropsychiatric symptoms (NPS) being non-integral associations. Emerging Evidence suggests that within typical AD, these symptoms are core features from the onset.
Methods: We employed K-modes clustering on 2483 cognitively impaired (CI) individuals (CDR ≥ 0.
From Choice to Justice: Disrupting the Binary Political Logics of Assisted Reproduction.
Health Hum Rights
December 2024
Associate professor of women, gender, and sexuality studies in the Frederik Meijer Honors College at Grand Valley State University, Allendale, Michigan, United States.
Reproductive rights and reproductive justice paradigms have long been viewed as incompatible, largely because of their divergent orientations to the notion of choice. According to this oppositional framing, reproductive rights approaches have centered the right of (white, middle-class, heterosexual) women to choose not to have children while reproductive justice organizing has focused on gendered, racialized, and classed obstacles to control over whether and how to have and raise children. Amid increasing examination of assisted reproductive technologies (ARTs) vis-à-vis human rights principles, I see an opportunity to narrow the perceived gap between the politics of rights and justice.
View Article and Find Full Text PDFPhenological and morphological variations of Oryza rufipogon and O. nivara in Sri Lanka and their evolutionary implications.
Sci Rep
December 2024
Institute of Botany State Key Laboratory of Systematic and Evolutionary Botany, Chinese Academy of Sciences, 100093, Beijing, China.
Phenological and morphological variation are widely viewed as a pivotal driver of ecological adaptation and speciation. Here, we investigate variation patterns of flowering phenology and morphological traits within and between O. rufipogon and O.
View Article and Find Full Text PDFIntegrating modern and herbal medicines in controlling malaria: experiences of orthodox healthcare providers in Ghana.
Arch Public Health
December 2024
Public Health and Tropical Medicine, James Cook University, Townsville, Queensland , 4811, Australia.
Background: In Ghana, the government has integrated herbal medicine into the formal healthcare system in response to widespread use of traditional remedies. However, empirical evidence supporting the contribution of integrated healthcare to malaria control remains limited. This study employed a phenomenological qualitative research design to explore the experiences of medical doctors and pharmacists from the coastal, forest and savannah regions of Ghana regarding the integration of modern and herbal medicine in the treatment and control of malaria.
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