AI Article Synopsis
- Chronic hemodialysis patients face high cardiovascular risks and increased chances of blood clots and bleeding.
- Factor XI inhibitors, such as fesomersen, may offer effective anticoagulation with a reduced risk of bleeding.
- A recent phase 2 study on fesomersen indicated it is safe for these patients and may lower clotting rates in dialysis systems.
Article Abstract
Chronic hemodialysis patients exhibit an excessive cardiovascular risk and a marked increase in both thromboembolism and bleeding episodes. Factor XI inhibition may provide anticoagulation, with a low risk of bleeding, and several factor XI inhibitors, including fesomersen, an antisense oligonucleotide, are under development. Recently, a phase 2 study of fesomersen showed a good safety profile in chronic hemodialysis patients and suggested that clotting rates of the arteriovenous fistula and the dialysis circuit are lower.
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| http://dx.doi.org/10.1016/j.kint.2024.03.029 | DOI Listing |
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