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Detection of Clinically Relevant Monogenic Copy-Number Variants by a Comprehensive Genome-Wide Microarray with Exonic Coverage.
Clin Chem
January 2025
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.
Background: Disease-causing copy-number variants (CNVs) often encompass contiguous genes and can be detected using chromosomal microarray analysis (CMA). Conversely, CNVs affecting single disease-causing genes have historically been challenging to detect due to their small sizes.
Methods: A custom comprehensive CMA (Baylor College of Medicine - BCM v11.
Asymmetric distribution of G-quadruplex forming sequences in genomes of retroviruses.
Sci Rep
January 2025
Institute of Biophysics, Czech Academy of Sciences , Královopolská 135, Brno, 612 65, Czech Republic.
Retroviruses are among the most extensively studied viral families, both historically and in contemporary research. They are primarily investigated in the fields of viral oncogenesis, reverse transcription mechanisms, and other infection-specific aspects. These include the integration of endogenous retroviruses (ERVs) into host genomes, a process widely utilized in genetic engineering, and the ongoing search for HIV/AIDS treatment.
View Article and Find Full Text PDFWell-being After Finalization of a Workers' Compensation Claim: A Cross-Sectional Survey.
J Occup Environ Med
January 2025
From the Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia (J.W., R.F., D.B.); Curtin enAble Institute, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia (R.F., B.M., D.B.); Pain Options, 7 Hardy Street, South Perth, Western Australia, Australia (T.M.); Centre for Health Research, University of Southern Queensland, Australia (V.J.); School of Health and Medical Sciences, University of Southern Queensland, Ipswich, Queensland, Australia (M.W.); Monash Centre for Occupational and Environmental Health (MonCOEH), Monash University, Melbourne, Victoria, Australia (M.W.); John Curtin Institute of Public Policy, Curtin University, Perth, Western Australia, Australia (R.G.); and Mental health, Alcohol, Substance Use and Tobacco Research Unit, South African Medical Research Council, Tygerberg, South Africa (B.M.).
Objective: Injured workers can be disadvantaged after a workers' compensation claims ends. This study investigated the association of a range of variables with well-being in injured workers who had finalized a workers' compensation claim >3 months prior.
Methods: On-line, cross-sectional survey (n = 129, 55.
Shining a spotlight on pulmonary hypertension associated with interstitial lung disease care: The latest advances in diagnosis and treatment.
J Manag Care Spec Pharm
January 2025
PRIME Education, New York City, NY.
Pulmonary hypertension associated with interstitial lung disease (PH-ILD) is a complex condition in which 2 consequential diseases interact and increase negative outcomes. Although the pathophysiologic mechanisms of PH-ILD are not yet well understood, the pronounced effect on functional status, supplemental oxygen requirements, health care resource utilization, and mortality that frequently accompany this diagnosis are well documented. A critical feature that complicates pathophysiologic understanding of PH-ILD is that progression of the pulmonary vascular disease does not always appear to be driven by the underlying lung disease.
View Article and Find Full Text PDFProvider capacity during Medicaid expansion and a public health emergency.
Am J Manag Care
December 2024
University of Missouri Truman School of Government and Public Affairs, 615 Locust St, E004 Locust Street Bldg, Columbia, MO 65211. Email:
Objectives: To assess the capacity of Medicaid providers to take on new patients during a time of unprecedented growth in program enrollment due to Medicaid expansion and the COVID-19 public health emergency.
Study Design: We conducted a survey of Medicaid providers in Missouri in 2023 about their patient load and capacity to accept new patients.
Methods: We recruited 141 Missouri Medicaid providers through probability sampling and 109 additional providers through convenience sampling for a total sample size of 250, representing 0.
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