AI Article Synopsis
- - Recent studies by Du et al., Balasubramanian et al., and Zhang et al. highlight the role of palmitoylation at cysteine positions 191/192 in gasdermin D.
- - This modification is crucial for gasdermin D's ability to move to cell membranes and form complexes (oligomerization).
- - Effective plasma membrane permeabilization, which occurs during a form of cell death called pyroptosis, relies on this palmitoylation process.
Article Abstract
Three recent publications by Du et al., Balasubramanian et al., and Zhang et al. identified palmitoylation on cysteine 191/192 in gasdermin D as a key determinant of gasdermin D membrane translocation and oligomerization, ensuring efficient plasma membrane permeabilization during pyroptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616718 | PMC |
| http://dx.doi.org/10.1016/j.molcel.2024.05.023 | DOI Listing |
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