AI Article Synopsis

  • The gut microbiota plays a significant role in how cancer patients respond to immune checkpoint inhibitors (ICIs), but there’s no clear definition of harmful dysbiosis.* -
  • Researchers analyzed fecal samples from 245 non-small cell lung cancer (NSCLC) patients, identifying specific bacterial species groups associated with either resistance or response to ICIs, resulting in the creation of a topological score (TOPOSCORE).* -
  • This TOPOSCORE was further validated in additional patient cohorts and transformed into a 21-bacterial probe set for qPCR scoring, suggesting it could serve as a dynamic tool for diagnosing intestinal dysbiosis and tailoring microbiota-focused treatments.*

Article Abstract

The gut microbiota influences the clinical responses of cancer patients to immunecheckpoint inhibitors (ICIs). However, there is no consensus definition of detrimental dysbiosis. Based on metagenomics (MG) sequencing of 245 non-small cell lung cancer (NSCLC) patient feces, we constructed species-level co-abundance networks that were clustered into species-interacting groups (SIGs) correlating with overall survival. Thirty-seven and forty-five MG species (MGSs) were associated with resistance (SIG1) and response (SIG2) to ICIs, respectively. When combined with the quantification of Akkermansia species, this procedure allowed a person-based calculation of a topological score (TOPOSCORE) that was validated in an additional 254 NSCLC patients and in 216 genitourinary cancer patients. Finally, this TOPOSCORE was translated into a 21-bacterial probe set-based qPCR scoring that was validated in a prospective cohort of NSCLC patients as well as in colorectal and melanoma patients. This approach could represent a dynamic diagnosis tool for intestinal dysbiosis to guide personalized microbiota-centered interventions.

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Source
http://dx.doi.org/10.1016/j.cell.2024.05.029DOI Listing

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