Awe-inspiring developmental biology is all around us. In this 50th Anniversary focus issue, we celebrate developmental biology with content paying homage to the incredible progress the field has witnessed over the last five decades as well as inspirational content looking forward toward what might lie ahead.
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| http://dx.doi.org/10.1016/j.cell.2024.05.042 | DOI Listing |
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Orthodontic Treatment of Anterior Open Bite Caused by a Car Accident.
Contemp Clin Dent
December 2024
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
This article outlines the orthodontic treatment of a 21-year-old female patient with an open bite and temporomandibular joint disorders (TMDs) that developed after a severe car accident. The treatment plan utilized temporary anchorage devices (TADs) for upper molar intrusion to correct the open bite without resorting to orthognathic surgery. Over a period of 3 years, the treatment achieved a stable occlusion, normalized molar relationships, and improved esthetics.
View Article and Find Full Text PDFLong-term dynamics of placozoan culture: emerging models for population and space biology.
Front Cell Dev Biol
January 2025
Departments of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL, United States.
As the simplest free-living animal, (Placozoa) is emerging as a powerful paradigm to decipher molecular and cellular bases of behavior, enabling integrative studies at all levels of biological organization in the context of metazoan evolution and parallel origins of neural organization. However, the progress in this direction also depends on the ability to maintain a long-term culture of placozoans. Here, we report the dynamic of cultures over 11 years of observations from a starting clonal line, including 7 years of culturing under antibiotic (ampicillin) treatment.
View Article and Find Full Text PDFHead-to-head: IL-21 triumphs over IL-15 in NK cell therapy for glioblastoma.
Acta Biochim Biophys Sin (Shanghai)
January 2025
Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47405, USA.
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology.
Mol Neurodegener
January 2025
Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, 92697-4545, USA.
Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to confer resistance to autosomal dominant Alzheimer's Disease (AD). However, it remains unclear whether and how this variant exerts its protective effects.
View Article and Find Full Text PDFMicrobial interactions lead to ecosystem function.
Nat Rev Microbiol
January 2025
Developmental Biology Unit, EMBL, Heidelberg, Germany.
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