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An Update on Advances in Hypopituitarism: Etiology, Diagnosis, and Current Management.
J Clin Med
October 2024
Department of Endocrinology and Nutrition, Hospital Universitario Puerta de Hierro Majadahonda, Calle Joaquín Rodrigo, 1, 28222 Majadahonda, Madrid, Spain.
Article Synopsis
- - This article reviews hypopituitarism (HP), a condition where the pituitary gland doesn't produce enough hormones, detailing its causes like tumors, genetic issues, and other factors such as trauma and medications.
- - Diagnosis involves clinical evaluations and hormonal tests, although these tests can have limitations; identifying specific hormonal deficiencies is critical for treatment.
- - Hormone replacement therapy is the main treatment for HP, improving patient quality of life, but awareness of potential interactions among therapies is crucial; ongoing research and a multidisciplinary approach are also highlighted for better management of the disorder.
Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors.
Front Endocrinol (Lausanne)
October 2024
Laboratory of Hormones and Molecular Genetics (LIM/42), Developmental Endocrinology Unit, Discipline of Endocrinology and Metabolism, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Introduction: Congenital hypopituitarism (CH) is characterized by the deficiency of pituitary hormones. Among CH patients, 85% lack a molecular diagnosis. Whole Exome Sequencing (WES) identified a homozygous variant (c.
View Article and Find Full Text PDFEfficacy of Gonadotropin Treatment for Induction of Spermatogenesis in Men With Pathologic Gonadotropin Deficiency: A Meta-Analysis.
Clin Endocrinol (Oxf)
February 2025
Department of Andrology, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
Introduction: Hypogonadotropic hypogonadism (HH) is a treatable cause of nonobstructive azoospermic male infertility. Gonadotropin treatment can successfully induce spermatogenesis in most patients, although comprehensive quantitative summary data on spermatogenic outcomes like those required to induce pregnancy is lacking in the literature.
Materials And Methods: Systematic review and meta-analysis of outcomes related to male reproductive function following gonadotropin treatment.
The molecular basis of hypoprolactinaemia.
Rev Endocr Metab Disord
December 2024
Department of Paediatric Endocrinology, Great Ormond Street Children's Hospital, London, UK.
Hypoprolactinaemia is an endocrinopathy which is typically encountered as part of a combined pituitary hormone deficiency picture. The vast majority of genetic causes identified to date have been in the context of congenital hypopituitarism with multiple co-existent endocrinopathies. This is primarily with its closest hormonal relation, namely growth hormone.
View Article and Find Full Text PDFProlactin deficiency in the context of other pituitary hormone abnormalities : Special issue: hypoprolactinemia: a neglected endocrine disorder.
Rev Endocr Metab Disord
December 2024
Institute of Endocrinology, Rabin Medical Center- Beilinson Hospital, 39 Jabotinksi St, Petach Tikva, 4941492, Israel.
Article Synopsis
- - Prolactin deficiency is uncommon and typically results from pituitary disorders such as large tumors and apoplexy, leading to hypopituitarism where prolactin is often the last hormone affected.
- - This deficiency can arise from various congenital syndromes and acquired conditions, including Sheehan syndrome and immune checkpoint-inhibitor-induced hypophysitis.
- - In women, low prolactin levels hinder lactation post-childbirth, but recombinant human prolactin has shown effectiveness in stimulating milk production in women with low levels.
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