Effect of cell therapy with adipose-derived stem cells in the treatment of acute rupture of the Achilles tendon in humans.

Cell Tissue Bank

Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso Do Sul - UFMS, Campo Grande, MS, Brasil.

Published: September 2024

AI Article Synopsis

  • - This study examined the impact of adipose-derived stem cells (ADSCs) on healing acute Achilles tendon ruptures in 15 patients, who were divided into three groups: one with ruptures only, one with surgical sutures, and one with ruptures treated using ADSCs.
  • - Results showed that the group receiving ADSCs had significantly higher scores on the AOFAS scale indicating better function, while both the suture and ADSC groups scored better on the ATRS scale compared to the rupture-only group.
  • - The study concluded that using ADSCs can enhance tissue regeneration and improve functional recovery, suggesting it could be a viable treatment option for Achilles tendon ruptures.

Article Abstract

The aim of this study was to evaluate the effect of adipose-derived stem cells (ADSCs) in the treatment of acute rupture of the Achilles tendon. It was a cross-sectional study involving 15 patients. Patients were randomly divided: group 1-rupture; group 2-suture; group 3-rupture + ADSCs. In the AOFAS score, the score was higher in group 3 with a significant difference. In the ATRS score, the score was higher in groups 2 and 3, also with a significant difference. As for the ultrasound score, there was a significant difference between the experimental groups in relation to this score, however, in the multiple comparisons test, comparing two groups at a time, it was possible to observe a significant difference of the experimental groups. It can be concluded that cell therapy in this condition may be a treatment option due to tissue regeneration and significant recovery of function.

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Source
http://dx.doi.org/10.1007/s10561-024-10141-4DOI Listing

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