To explore the antifungal potential of Sanghuang mushroom, a traditional Chinese medicine. The antifungal properties and the potential mechanism of Sanghuang mushroom extracts against were studied and . Sanghuang mushroom extracts inhibited the biofilm formation, increased the cell membrane permeability and promoted cell apoptosis of . In a murine model of vulvovaginal candidiasis, Sanghuang mushroom extracts reduced the vaginal fungal load, improved inflammatory cell infiltration and downregulated the expression of TNF-α, IL-1β and IL-6. Untargeted metabolomic analysis suggested the presence of ten antifungal components in Sanghuang mushroom extracts. Sanghuang mushroom extracts showed promise as antifungal agent against candidiasis, with potential therapeutic implications.
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| http://dx.doi.org/10.1080/17460913.2024.2352269 | DOI Listing |
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