AI Article Synopsis
- The study compares patterns of multimorbidity in over 103,000 individuals with rheumatic and musculoskeletal diseases (RMDs) to 2.9 million people without RMDs from 2010 to 2019.
- The research found that those with RMDs had significantly higher odds of various comorbidities, such as hypertension and diabetes, with 81% experiencing multiple conditions compared to 73% in the non-RMD group by 2019.
- The findings suggest that individuals with RMDs are about 1.5 times more likely to have additional health issues, indicating a need for targeted healthcare interventions for this high-risk population.
Article Abstract
Objectives: To compare the patterns of multimorbidity between people with and without rheumatic and musculoskeletal diseases (RMDs) and to describe how these patterns change by age and sex over time, between 2010 and 2019.
Participants: 103 426 people with RMDs and 2.9 million comparators registered in 395 Wales general practices (GPs). Each patient with an RMD aged 0-100 years between January 2010 and December 2019 registered in Clinical Practice Research Welsh practices was matched with up to five comparators without an RMD, based on age, gender and GP code.
Primary Outcome Measures: The prevalence of 29 Elixhauser-defined comorbidities in people with RMDs and comparators categorised by age, gender and GP practices. Conditional logistic regression models were fitted to calculate differences (OR, 95% CI) in associations with comorbidities between cohorts.
Results: The most prevalent comorbidities were cardiovascular risk factors, hypertension and diabetes. Having an RMD diagnosis was associated with a significantly higher odds for many conditions including deficiency anaemia (OR 1.39, 95% CI (1.32 to 1.46)), hypothyroidism (OR 1.34, 95% CI (1.19 to 1.50)), pulmonary circulation disorders (OR 1.39, 95% CI 1.12 to 1.73) diabetes (OR 1.17, 95% CI (1.11 to 1.23)) and fluid and electrolyte disorders (OR 1.27, 95% CI (1.17 to 1.38)). RMDs have a higher proportion of multimorbidity (two or more conditions in addition to the RMD) compared with non-RMD group (81% and 73%, respectively in 2019) and the mean number of comorbidities was higher in women from the age of 25 and 50 in men than in non-RMDs group.
Conclusion: People with RMDs are approximately 1.5 times as likely to have multimorbidity as the general population and provide a high-risk group for targeted intervention studies. The individuals with RMDs experience a greater load of coexisting health conditions, which tend to manifest at earlier ages. This phenomenon is particularly pronounced among women. Additionally, there is an under-reporting of comorbidities in individuals with RMDs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191776 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2023-079169 | DOI Listing |
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