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Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study. | LitMetric

AI Article Synopsis

  • - The study investigates the association between the triglyceride glucose (TyG) index and breast cancer risk in Chinese women, using data from a large sample of 142,184 participants aged 40 or older.
  • - Results indicate that women in the highest quartile of the TyG index have a 61% increased risk of prevalent breast cancer compared to those in the lowest quartile, with certain demographics showing even stronger associations.
  • - The findings suggest that the TyG index may be a useful marker for assessing breast cancer risk, especially among women without insulin resistance or metabolic issues.

Article Abstract

Background: The triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.

Methods: This cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.

Results: Multivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19-2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13-17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09-1.68), 1.27 (1.05-1.54), 1.26 (1.05-1.52), and 1.32 (1.08-1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] ≥2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44-3.87).

Conclusion: The TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186986PMC
http://dx.doi.org/10.3389/fendo.2024.1321622DOI Listing

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