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| http://dx.doi.org/10.3389/fimmu.2024.1411391 | DOI Listing |
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Differential tumor immune microenvironment coupled with tumor progression or tumor eradication in HPV-antigen expressing squamous cell carcinoma (SCC) models.
Front Immunol
July 2024
University of Pittsburgh Medical Center UPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Human papilloma virus (HPV) is an etiological factor of head and neck squamous cell carcinoma (HNSCC). To investigate the role of HPV antigen in anti-tumor immunity, we established mouse models by expressing HPV16 E6 and E7 in a SCC tumor cell line. We obtained two HPV antigen-expressing clones (C-225 and C-100) transplantable into C57BL/6 recipients.
View Article and Find Full Text PDFMyelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors.
Front Immunol
July 2024
Center for Childhood Cancer Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Article Synopsis
- Malignant peripheral nerve sheath tumors (MPNST) are tough to treat because they often come back after surgery and don't respond well to regular chemotherapy.
- A new treatment called oncolytic viroimmunotherapy, which uses viruses to help fight tumors, shows promise but doesn’t work for everyone, so more research is needed to improve it.
- In experiments, using specific drugs along with the oncolytic virus helped some mice live longer by boosting their immune response against the tumors, leading to less suppressive cells in the tumor area, though the tumors didn’t shrink.
MDSCs use a complex molecular network to suppress T-cell immunity in a pulmonary model of fungal infection.
Front Cell Infect Microbiol
July 2024
Institute of Science and Technology, Federal University of São Paulo - UNIFESP, São Paulo, Brazil.
Article Synopsis
- Paracoccidioidomycosis (PCM) is a systemic fungal disease found mainly in Latin America, and various immune suppressive mechanisms regulate the host's immune response to it, including tolerogenic dendritic cells and regulatory T-cells.
- This study investigates how receptors like Dectin-1, TLR2, and TLR4 affect the production of immunosuppressive molecules by myeloid-derived suppressor cells (MDSCs) during fungal infections in the lungs.
- Results showed that blocking Dectin-1, TLR2, and TLR4 significantly reduced levels of immunosuppressive molecules such as IL-10 and nitrotyrosine, leading to decreased suppressive activity of MDS
The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer.
Front Immunol
July 2024
Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Background: Mobilization of certain immune cells may improve the ability of the immune system to combat tumor cells, but the effect of acute exercise on mobilizing immune cells has been sparsely investigated in cancer patients. Therefore, we examined how acute exercise influences circulating immune cells in breast cancer patients.
Methods: Nineteen newly diagnosed breast cancer patients aged 36-68 performed 30 minutes of moderate-intensity exercise with a cycle ergometer.
Editorial: Myeloid-derived suppressor cells in health and diseases: harnessing their roles in the development of new immunotherapy approaches.
Front Immunol
June 2024
Institute for the Application of Nuclear Energy, University of Belgrade, Belgrade, Serbia.
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