Middle cerebral artery dissection (MCAD) is a rare condition with no consensus on its treatment strategy and prognosis. This report describes a case of MCAD with perforating artery infarction in which radiographic findings progressed despite a lack of symptoms following maintenance infusion without antithrombotic therapy. A five-year-old boy presented to our hospital with right hemiplegia. Magnetic resonance imaging revealed diffusion restriction in the left basal ganglia. Additionally, magnetic resonance angiography (MRA) revealed irregular walls in the horizontal portion of the left middle cerebral artery. MRA performed three months after admission revealed progressive stenosis but no new ischemic lesions. MCAD can be associated with long-term morphological changes in the vessel walls. Intracranial artery dissection (IAD) in pediatric patients often presents without headache or neck pain, and serial imaging helps monitor disease progression. In conclusion, the morphology of the vessels can change over several months. Especially in pediatric patients, IAD often presents without headache or neck pain, and serial imaging evaluations help monitor disease progression.
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http://dx.doi.org/10.7759/cureus.60625 | DOI Listing |
Metab Brain Dis
January 2025
Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases of Ministry of Education, Gannan Medical University, Ganzhou, 341000, China.
Cerebral ischemia-induced pyroptosis contributes to the dissemination of neuroinflammation, and Nod-like receptor protein-3 (NLRP3) inflammasome plays a key role in this process. Previous studies have indicated that Genistein-3'-sodiumsulfonate (GSS) can inhibit neuroinflammation caused by cerebral ischemia, exert cerebroprotective effects, but its specific mechanism has not been comprehensively understood. The aim of this study was to explore the effect of GSS on ischemic stroke-induced cell pyroptosis.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Kobayashi Hospital, 510 Imaichi, Izumo City, Shimane, 693-0001, Japan.
Adverse effects of advanced age and poor initial neurological status on outcomes of patients with aneurysmal subarachnoid hemorrhage (SAH) have been documented. While a predictive model of the non-linear correlation between advanced age and clinical outcome has been reported, no previous model has been validated. Therefore, we created a prediction model of the non-linear correlation between advanced age and clinical outcome by machine learning and validated it using a separate cohort.
View Article and Find Full Text PDFCranioplasty is an operation that aims to repair a defect in the skull. Indications commonly include Traumatic Brain Injury (TBI), tumours, and infections. It carries a high rate of postoperative morbidity.
View Article and Find Full Text PDFJ Mol Neurosci
January 2025
Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Hemorrhagic stroke is a known complication of glioma, yet the underlying mechanisms remain poorly understood. This study aims to investigate key biomarkers of glioma-related hemorrhage to provide insights into glioma molecular therapies. Data were obtained from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) databases to analyze differentially expressed genes (DEGs) in glioma by contrasting glioblastoma (GBM) with low-grade gliomas (LGGs).
View Article and Find Full Text PDFEmergencias
December 2024
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seúl, República de Corea. Department of Digital Health, SAIHST, Sungkyunkwan University, Seúl, República de Corea.
Objective: To develop a Metabolic Derangement Score (MDS) based on parameters available after initial testing and assess the score's ability to predict survival after out-of hospital cardiac arrest (OHCA) and the likely usefulness of extracorporeal life support (ECLS).
Methods: A total of 5100 cases in the Korean Cardiac Arrest Research Consortium registry were included. Patients' mean age was 67 years, and 69% were men.
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