AI Article Synopsis
- Two new compounds, osmjapterpenoid A and osmunjaponin A, were isolated from the roots of Thunb, alongside twenty-six known compounds.
- The chemical structures of these compounds were analyzed using advanced techniques like 1D and 2D-NMR and HR-ESI-MS, revealing that osmjapterpenoid A has a unique 5/13 dicyclic ring structure.
- Both new compounds showed moderate inhibition of nitric oxide production in macrophage cells, with IC values of 32.09 μM for osmjapterpenoid A and 19.81 μM for osmunjaponin A.
Article Abstract
Two new compounds, osmjapterpenoid A () and osmunjaponin A (), along with twenty-six known compounds, were isolated from the roots and rhizomes of Thunb. The chemical structures of them were elaborated by extensive spectroscopic means, including 1D, 2D-NMR and HR-ESI-MS. Compound is a diterpenoid derived from cembrane with a novel skeleton of 5/13 dicyclic ring system. The possible biogentic pathway of was deduced. Compounds and exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC value of 32.09 and 19.81 μM, respectively.
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| http://dx.doi.org/10.1080/14786419.2024.2362427 | DOI Listing |
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