AI Article Synopsis
- - The study compares the safety of nasogastric (NG) feeding and nasojejunal (NJ) feeding in patients with acute pancreatitis (AP), focusing on feeding initiated within the first 48 hours of hospital admission.
- - Analysis of 217 patients from four studies revealed similar mortality rates for both feeding methods, but NG feeding was associated with higher instances of diarrhea, pain, and infections compared to NJ feeding.
- - The findings suggest that while NG feeding can lead to more complications, it does not significantly affect mortality rates or the need for surgery, emphasizing the need to carefully choose feeding methods during early treatment.
Article Abstract
Background: The primary objective of this study is to comparatively assess the safety of nasogastric (NG) feeding versus nasojejunal (NJ) feeding in patients with acute pancreatitis (AP), with a special focus on the initiation of these feeding methods within the first 48 h of hospital admission.
Methods: Studies were identified through a systematic search in PubMed, EMbase, Cochrane Central Register of Controlled Trials, and Web of Science. Four studies involving 217 patients were included. This systematic review assesses the safety and efficacy of nasogastric versus nasojejunal feeding initiated within 48 h post-admission in moderate/severe acute pancreatitis, with a specific focus on the timing of initiation and patient age as influential factors.
Results: The results showed that the mortality rates were similar between NG and NJ feeding groups (RR 0.86, 95% CI 0.42 to 1.77, P = 0.68). Significant differences were observed in the incidence of diarrhea (RR 2.75, 95% CI 1.21 to 6.25, P = 0.02) and pain (RR 2.91, 95% CI 1.50 to 5.64, P = 0.002) in the NG group. The NG group also showed a higher probability of infection (6.67% vs. 3.33%, P = 0.027) and a higher frequency of multiple organ failures. Subgroup analysis for early intervention (within 48 h) showed a higher risk of diarrhea in the NG group (RR 2.80, P = 0.02). No significant differences were found in the need for surgical intervention, parenteral nutrition, or success rates of feeding procedures.
Conclusion: This meta-analysis highlights the importance of considering the method and timing of nutritional support in acute pancreatitis. While NG feeding within 48 h of admission increases the risk of certain complications such as diarrhea and infection, it does not significantly impact mortality or the need for surgical intervention.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188158 | PMC |
| http://dx.doi.org/10.1186/s12876-024-03290-z | DOI Listing |
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