AI Article Synopsis
- The study focuses on the rare occurrence of primary mesenchymal breast tumors, which are less common than epithelial tumors, aiming to detail their histomorphological and clinicoradiological characteristics.
- Out of 26 cases studied between 2010 and 2023, over half were benign (like hemangiomas and lipomas), while nearly half were malignant, with findings like angiosarcoma being observed.
- The conclusion emphasizes that primary breast sarcomas are very rare and recommend thorough sampling and examination of clinical and radiological data to rule out phyllodes tumors or metastasis when identifying mesenchymal tumors.
Article Abstract
Objective: While the majority of breast neoplasms originate from epithelial cells, a rare part of them originate from mesenchymal breast tissue. This study aims to present the histomorphological and clinicoradiological features of our series of primary mesenchymal breast tumors and to discuss the features of these tumors in light of the literature.
Materials And Methods: Cases diagnosed as primary mesenchymal breast tumor in breast resection materials evaluated in our center between 2010 and 2023 were included.
Results: Of the 26 tumors included, 57.7% were diagnosed as benign and 42.3% as malignant mesenchymal tumor. Cases diagnosed as benign mesenchymal tumor were hemangioma, lipoma, extra-abdominal fibromatosis, leiomyoma, angiofibroma, lipomatosis, benign fibrous histiocytoma and granular cell tumor. Histopathological study results were compatible with angiosarcoma in 5 (45.4%), undifferentiated sarcoma in 3 (27.3%), myxofibrosarcoma in 2 (18.2%) cases and rhabdomyosarcoma in 1 (9.1%) case.
Conclusion: Primary breast sarcomas are rarely seen compared to benign mesenchymal tumors and constitute less than 0.1% of all malignant breast tumors. When histomorphological findings suggestive of a mesenchymal tumor are observed in breast specimens, sufficient sampling should be performed to exclude a possible phyllodes tumor, and clinicoradiological findings should be examined to exclude the possibility of a metastasis.
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| http://dx.doi.org/10.1007/s12094-024-03544-y | DOI Listing |
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