AI Article Synopsis
- This research showcases a new method for converting acetamides into functionalized amides using copper as a catalyst, incorporating alcohols through a process called borrowing hydrogen.
- The process is straightforward, utilizing readily available Cu(OAc) as a precatalyst without needing extra ligands or complex metal structures, making it simpler than previous methods.
- Mechanistic studies identify aldehyde and α,β-unsaturated amides as key intermediates, highlighting the copper's role in facilitating alcohol dehydrogenation and hydrogenating C═C bonds.
Article Abstract
We report the first example of copper-catalyzed α-alkylation of acetamides with alcohols via a borrowing hydrogen strategy. Catalyzed by the -generated copper particles, acetamides and various substituted benzyl or alkyl alcohols were transformed into functionalized amides in good yields with excellent selectivity. Compared with previous work, this process is simple using commercially available Cu(OAc) as a precatalyst, without an additional ligand or a metal complex, and easier. Mechanistic studies revealed that aldehyde and α,β-unsaturated amides were the intermediates of this reaction and also disclosed the role of copper in alcohol dehydrogenation and C═C bond hydrogenation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.4c00404 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!