AI Article Synopsis

  • * These enzymes are linked to two different pathways that produce two main types of metabolites: phenylphenalenones and linear diarylheptanoid derivatives.
  • * We showed how dihydrobisdemethoxycurcumin is gradually converted into a specific phenylphenalenone by using root protein extracts with added intermediates.

Article Abstract

Here, we use transcriptomic data from seeds of to identify five enzymes involved in the formation of dihydrocurcuminoids. Characterization of the substrate specificities of the enzymes reveals two distinct dihydrocurcuminoid pathways leading to phenylphenalenones and linear diarylheptanoid derivatives, the major seed metabolites. Furthermore, we demonstrate the stepwise conversion of dihydrobisdemethoxycurcumin to the phenylphenalenone 4'-hydroxylachnanthocarpone by feeding intermediates to root protein extract.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232022PMC
http://dx.doi.org/10.1021/acs.orglett.4c01750DOI Listing

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