Here, we use transcriptomic data from seeds of to identify five enzymes involved in the formation of dihydrocurcuminoids. Characterization of the substrate specificities of the enzymes reveals two distinct dihydrocurcuminoid pathways leading to phenylphenalenones and linear diarylheptanoid derivatives, the major seed metabolites. Furthermore, we demonstrate the stepwise conversion of dihydrobisdemethoxycurcumin to the phenylphenalenone 4'-hydroxylachnanthocarpone by feeding intermediates to root protein extract.
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http://dx.doi.org/10.1021/acs.orglett.4c01750 | DOI Listing |
Molecules
January 2025
School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Dopamine (DA) is an important catecholamine neurotransmitter and its abnormal concentration is closely related to diseases such as hypertension, Parkinson's disease and schizophrenia. Due to the advantages of high sensitivity and fast response for electrochemiluminescence (ECL), developing ECL sensors for detecting DA was very critical in clinical diagnosis. ECL resonance energy transfer (ECL-RET) was an effective signaling mechanism.
View Article and Find Full Text PDFMolecules
November 2024
School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.
Ascorbic acid plays an important role in the synthesis and metabolism of the human body. However, it cannot be synthesized by the human body and needs to be supplemented from exogenous food intake. Ascorbic acid is easily degraded during storage and heating, often causing its content in food to change.
View Article and Find Full Text PDFMikrochim Acta
October 2024
Chemistry of Department, Liaocheng University, Liaocheng, 252059, Shandong, China.
The self-assembly material N,N-bis-(3-dimethyl aminopropyl)-3,4,9,10-perylene tetracarboxylic acid diimide (PDI) is reported to show electrochemical (EC)/electrochemiluminescence (ECL) property for designing new dual-mode dopamine (DA) sensors. KSO significantly improved the EC reduction current at -0.346 V and ECL intensity at -0.
View Article and Find Full Text PDFFood Chem
February 2025
Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus (54000), Pakistan. Electronic address:
Meat spoilage has been acquiring increasing attention recently and is directly associated with food safety and human health. Biogenic amines are the spying organic compounds fostered from the microorganism-mediated decarboxylation of amino acids during meat spoilage. Histamine, a biogenic amine acts as a model analyte and is toxic if consumed substantially.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2024
Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.
The lipopolyplex, a multicomponent nonviral gene carrier, generally demonstrates superior colloidal stability, reduced cytotoxicity, and high transfection efficiency. In this study, a new concept, photochemical reaction-induced transfection, using photosensitizer (PS)-loaded lipopolyplexes was applied, which led to enhanced transfection and cytotoxic effects by photoexcitation of the photosensitizer. Hypericin, a hydrophobic photosensitizer, was encapsulated in the lipid bilayer of liposomes.
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