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More micrometastases, more recurrence? The role of qPCR of PSA mRNA in lymph nodes during prostatectomy.
World J Urol
January 2025
Department of Urology, Urooncology, Robot-assisted and Focal Therapy, University Hospital Magdeburg, Otto-von Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Background And Objectives: Radical prostatectomy is a standard treatment for prostate cancer, yet about 30% of patients experience rising biochemical markers within a decade post-surgery. Pelvic lymph node sampling during prostatectomy assesses potential lymph node metastases, but standard histological assessments, which typically examine only 2-3 tissue sections, often miss occult metastases. This study assesses the effectiveness of qPCR in detecting PSA coding KLK3 mRNA for identifying lymph node metastases post-prostatectomy and explores the correlation between PSA-mRNA and biochemical recurrence.
View Article and Find Full Text PDFEarly detection efforts for colorectal and prostate cancer from the patient's perspective over the course of 12 years: results of the KABOT survey study.
Prim Health Care Res Dev
December 2024
Institute of General Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Aim: This study investigates the level of knowledge and utilization of colorectal cancer (CRC) and prostate cancer (PCa) early detection measures (EDMs) over a period of 12 years in general practice from the patient's perspective.
Background: The role of general practitioners (GPs) in EDMs for CRC and PCa in Germany is not well-documented with comprehensive data.
Methods: We conducted a patient-centric survey in the German federal state of Berlin-Brandenburg at a 12-year interval to examine the role of GPs in EDMs for CRC and PCa.
Translating evidence into practice: Managing electrolyte imbalances and iron deficiency in heart failure.
Eur J Intern Med
November 2024
Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Lower Saxony, Germany. Electronic address:
Article Synopsis
- Mineral abnormalities, including dyskalaemia, hyponatraemia, hypomagnesaemia, and iron deficiency, are common in heart failure (HF) and are linked to worse health outcomes and increased mortality rates.
- The imbalance in these minerals is influenced by factors like neurohumoral activation, effects of HF medications, and chronic conditions like kidney disease.
- Iron deficiency, affecting up to 60% of HF patients, is particularly serious, but iron replacement therapy has shown benefits, especially in patients with reduced and preserved ejection fractions.
Fire, , , and Alchemy: A Hybrid Close-Distant Reading of Paracelsus's Thought on Active Agents.
Ambix
August 2024
History Faculty, University of Oxford, Oxford, UK.
The Swiss physician and philosopher Theophrastus von Hohenheim, called Paracelsus (1493-1541) is known for his strong advocacy of medical alchemy. That his natural philosophy was tied to medical alchemy is perhaps uncontroversial, but just how it was so is less straightforward. This article provides an insight into the connection between the two by means of Paracelsus's concept of active agents, with an emphasis on fire, its master , and the associated term .
View Article and Find Full Text PDFOccult von Willebrand Disease Complicating Mohs Surgery.
Dermatol Surg
December 2024
All authors are affiliated with the Medical University of South Carolina, Charleston, South Carolina.
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